N-(2-ethylphenyl)-2-methylbutanamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2-ethylphenyl)-2-methylbutanamide
• 化学式: C₁₃H₁₉NO
• mdl: MFCD02577220
• 分子量: 205.3
• InChiKey: LPBCMMVCHQDCBE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.461
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• [EN] AMIDINE COMPOUNDS<br/>[FR] COMPOSES D'AMIDINE
  申请人：UNIV MONASH

  公开号：WO2004033458A1

  公开（公告）日：2004-04-22

  Amidine derivatives of opioids of the formula YN-X-(NH)n-C(=NR)-R' in which YN is a morphine-like opioid radical; X is a direct bond, a substituted or unsubstituted, branched, straight-chained or cyclic alkylene having from 1 to 6 carbon atoms, optionally containing one or two heteroatoms in the alkyl chain, or an optionally substituted, branched or straight-chained alkenylene having from 4 to 10 carbon atoms; R and R' are independently hydrogen, alkyl, substituted alkyl, alkene, substituted alkene, alkyne, substituted alkyne, aryl, substituted aryl, heterocycle, substituted heterocycle or cyano; and n is 0 when X is said direct bond, or n is 1 when X is said alkylene or alkenylene. The compounds are effective in treating pain, and have effect in the peripheral nervous system, with comparably less or no activity in the central nervous system.

  阿米丁类阿片类药物的衍生物的化学式为YN-X-(NH)n-C(=NR)-R'，其中YN是类似吗啡的阿片类基团；X是直链键，取代或未取代，分支、直链或环状的烷基，含有1至6个碳原子，可选地在烷基链中含有一到两个杂原子，或者是含有4至10个碳原子的可取代、分支或直链的烯基；R和R'分别是氢、烷基、取代烷基、烯烃、取代烯烃、炔烃、取代炔烃、芳基、取代芳基、杂环、取代杂环或氰基；n为0时，X为所述的直链键，或者n为1时，X为所述的烷基或烯基。这些化合物对治疗疼痛有效，并在外周神经系统中具有作用，在中枢神经系统中具有相对较少或无活性。
• Amidine compounds
  申请人：Jackson Roy William

  公开号：US20060111381A1

  公开（公告）日：2006-05-25

  Amidine derivatives of opioids of the formula YN—X—(NH)n-C(═NR)—R′ in which YN is a morphine-like opioid radical; X is a direct bond, a substituted or unsubstituted, branched, straight-chained or cyclic alkylene having from 1 to 6 carbon atoms, optionally containing one or two heteroatoms in the alkyl chain, or an optionally substituted, branched or straight-chained alkenylene having from 4 to 10 carbon atoms; R and R′ are independently hydrogen, alkyl, substituted alkyl, alkene, substituted alkene, alkyne, substituted alkyne, aryl, substituted aryl, heterocycle, substituted hetercycle or cyano; and n is 0 when X is said direct bond, or n is 1 when X is said alkylene or alkenylene. The compounds are effective in treating pain, and have effect in the peripheral nervous system, with comparably less or no activity in the central nervous system.

  公式为YN—X—(NH)n-C(═NR)—R′的阿米啡衍生物，其中YN为类似吗啡的阿米啡基团；X为直接键，具有1到6个碳原子的取代或未取代的分支、直链或环烷基，可包含1或2个杂原子在烷基链中，或具有4到10个碳原子的可选取代、分支或直链烯基；R和R′独立地为氢、烷基、取代烷基、烯烃、取代烯烃、炔烃、取代炔烃、芳基、取代芳基、杂环、取代杂环或氰基；当X为直接键时，n为0，当X为烷基或烯基时，n为1。这些化合物对于治疗疼痛有效，并在周围神经系统中具有作用，与中枢神经系统相比具有较少或没有活性。
• AMIDINE COMPOUNDS
  申请人：Monash University

  公开号：EP1558617A1

  公开（公告）日：2005-08-03
• EP1558617A4
  申请人：——

  公开号：EP1558617A4

  公开（公告）日：2007-07-11