N-[2-[4-amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]ethyl]-N,2-dimethylprop-2-enamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[2-[4-amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]ethyl]-N,2-dimethylprop-2-enamide
• 化学式: C₂₄H₂₄N₆O₂
• 分子量: 428.5
• InChiKey: WRPAZPGZINEBIX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  32
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  99.2
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Use of inhibitors of Bruton'S tyrosine kinase (Btk)
  申请人：Pharmacyclics LLC

  公开号：US10004745B2

  公开（公告）日：2018-06-26

  Disclosed herein are methods for treating a cancer comprising: a. administering a Btk inhibitor to a subject sufficient to result in an increase or appearance in the blood of a subpopulation of lymphocytes defined by immunophenotyping; b. determining the expression profile of one or more biomarkers from one or more subpopulation of lymphocytes; and c. administering a second agent based on the determined expression profile.

  本文公开了治疗癌症的方法，包括：a.向受试者施用Btk抑制剂，足以导致血液中通过免疫分型确定的淋巴细胞亚群增加或出现；b.确定来自一个或多个淋巴细胞亚群的一个或多个生物标志物的表达谱；以及c.根据确定的表达谱施用第二种制剂。
• USE OF INHIBITORS OF BRUTON'S TYROSINE KINASE (BTK)
  申请人：Pharmacyclics LLC

  公开号：US20170035762A1

  公开（公告）日：2017-02-09

  Disclosed herein are methods for treating a cancer comprising: a. administering a Btk inhibitor to a subject sufficient to result in an increase or appearance in the blood of a subpopulation of lymphocytes defined by immunophenotyping; b. determining the expression profile of one or more biomarkers from one or more subpopulation of lymphocytes; and c. administering a second agent based on the determined expression profile.
• INHIBITORS OF BRUTON'S TYROSINE KINASE FOR THE TREATMENT OF SOLID TUMORS
  申请人：Pharmacyclics LLC

  公开号：US20200289515A1

  公开（公告）日：2020-09-17

  Described herein are irreversible Btk inhibitor compounds, and methods for using such irreversible inhibitors in the treatment of diseases and disorders characterized by the presence or development of solid tumors.
• US9801881B2
  申请人：——

  公开号：US9801881B2

  公开（公告）日：2017-10-31