6-amino-3-(thiophen-2-yl)-4-(p-tolyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 6-amino-3-(thiophen-2-yl)-4-(p-tolyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile
• 英文别名: 6-Amino-3-thiophen-2-yl-4-p-tolyl-1,4-dihydro-pyrano[2,3-c]pyrazole-5-carbonitrile；6-amino-4-(4-methylphenyl)-3-thiophen-2-yl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile
• 化学式: C₁₈H₁₄N₄OS
• 分子量: 334.401
• InChiKey: FBLFWPDHQSZVIA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  116
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• 6-amino-2,4-dihydropyrano [2,3-c] pyrazoles and methods of use
  申请人：Purdue Research Foundation

  公开号：US10980781B2

  公开（公告）日：2021-04-20

  The present invention generally relates to 6-amino-2,4-dihydropyrano [2,3-c] pyrazoles as a ubiquitin specific protease 7(USP7) inhibitor useful for the treatment of diseases mediated by malfunction of USP7, such as inflammation, cancer, and immunological disorders. The invention described herein also pertains to pharmaceutical compositions and methods for treating diseases mediated by malfunction of USP7, in mammals using compounds disclosed herein.

  本发明一般涉及作为泛素特异性蛋白酶7（USP7）抑制剂的6-氨基-2,4-二氢吡喃并[2,3-c]吡唑，可用于治疗由USP7功能失调介导的疾病，如炎症、癌症和免疫紊乱。本文所述的发明还涉及使用本文公开的化合物治疗哺乳动物中由 USP7 功能失常介导的疾病的药物组合物和方法。
• 6-AMINO-2,4-DIHYDROPYRANO [2,3-C] PYRAZOLES AND METHODS OF USE
  申请人：Purdue Research Foundation

  公开号：US20200078336A1

  公开（公告）日：2020-03-12

  The present invention generally relates to 6-amino-2,4-dihydropyrano [2,3-c] pyrazoles as a ubiquitin specific protease 7 (USP7) inhibitor useful for the treatment of diseases mediated by malfunction of USP7, such as inflammation, cancer, and immunological disorders. The invention described herein also pertains to pharmaceutical compositions and methods for treating diseases mediated by malfunction of USP7, in mammals using compounds disclosed herein.