1-Methyl-2-propan-2-yl-3-propoxybenzene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-Methyl-2-propan-2-yl-3-propoxybenzene
• 英文别名: 1-methyl-2-propan-2-yl-3-propoxybenzene
• 化学式: C₁₃H₂₀O
• 分子量: 192.3
• InChiKey: YYFNVGGKLMMTGG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• DIARYL SUBSTITUTED 5,5-FUSED RING COMPOUNDS AS C5aR INHIBITORS
  申请人：CHEMOCENTRYX, INC.

  公开号：US20190194208A1

  公开（公告）日：2019-06-27

  The present disclosure provides, inter alia, Compounds of Formula (I) or pharmaceutically acceptable salts thereof that are modulators of the C5a receptor. Also provided are pharmaceutical compositions and methods of use including the treatment of diseases or disorders involving pathologic activation from C5a and non-pharmaceutical applications.

  本公开提供了化合物的公式(I)或其药学上可接受的盐，这些化合物是C5a受体的调节剂。还提供了包括治疗涉及C5a病理激活的疾病或紊乱的药物组合物和使用方法，以及非药物应用。
• NOVEL BROMINATED FURANONE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT
  申请人：SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION

  公开号：US20190345126A1

  公开（公告）日：2019-11-14

  The present invention relates to a novel brominated furanone derivative, a method for preparing the same, and a pharmaceutical composition containing the same as an active ingredient, wherein the novel brominated furanone derivative or a pharmaceutically acceptable 5 salt thereof according to the present invention exhibits a quorum sensing inhibitory activity of bacteria and also can effectively inhibit the formation of biofilm of bacteria, and thus can be used as a pharmaceutical composition containing the same as an active ingredient, thereby having an effect of being useful, 10 for example, for periodontal diseases such as gingivitis and periodontitis, oral diseases, and the like.

  本发明涉及一种新型溴化呋喃酮衍生物，一种制备方法，以及一种含有该新型溴化呋喃酮衍生物作为活性成分的药物组合物，其中根据本发明，该新型溴化呋喃酮衍生物或其药用可接受的盐表现出细菌的群体感应抑制活性，还可以有效抑制细菌生物膜的形成，因此可以用作含有该物质作为活性成分的药物组合物，从而具有在牙周病如牙龈炎和牙周炎、口腔疾病等方面具有有用作用的效果。
• Diaryl substituted 5,5-fused ring compounds as C5aR inhibitors
  申请人：CHEMOCENTRYX, INC.

  公开号：US10759807B2

  公开（公告）日：2020-09-01

  The present disclosure provides, inter alia, Compounds of Formula (I) or pharmaceutically acceptable salts thereof that are modulators of the C5a receptor. Also provided are pharmaceutical compositions and methods of use including the treatment of diseases or disorders involving pathologic activation from C5a and non-pharmaceutical applications.

  本公开特别提供了式 (I) 化合物 或其药学上可接受的盐，它们是 C5a 受体的调节剂。此外，还提供了药物组合物和使用方法，包括治疗涉及 C5a 病理激活的疾病或失调以及非药物应用。
• Brominated furanone derivative, method for preparing same, and pharmaceutical composition containing same as active ingredient
  申请人：SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION

  公开号：US11021455B2

  公开（公告）日：2021-06-01

  The present invention relates to a novel brominated furanone derivative, a method for preparing the same, and a pharmaceutical composition containing the same as an active ingredient, wherein the novel brominated furanone derivative or a pharmaceutically acceptable 5 salt thereof according to the present invention exhibits a quorum sensing inhibitory activity of bacteria and also can effectively inhibit the formation of biofilm of bacteria, and thus can be used as a pharmaceutical composition containing the same as an active ingredient, thereby having an effect of being useful, 10 for example, for periodontal diseases such as gingivitis and periodontitis, oral diseases, and the like.

  本发明涉及一种新型溴化呋喃酮衍生物、其制备方法以及含有该衍生物作为活性成分的药物组合物，其中根据本发明的新型溴化呋喃酮衍生物或其药学上可接受的 5 盐显示出对细菌的法定量感应抑制活性，并且还可以有效抑制细菌生物膜的形成、因此可用作含有其作为活性成分的药物组合物，从而具有对牙龈炎和牙周炎等牙周疾病、口腔疾病等有用的效果。