1-[(3-Fluorophenyl)methyl]azetidine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-[(3-Fluorophenyl)methyl]azetidine
• 英文别名: 1-[(3-fluorophenyl)methyl]azetidine
• 化学式: C₁₀H₁₂FN
• 分子量: 165.21
• InChiKey: QVJZMLGSAGZLSV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] PIPERIDINE COMPOUNDS AS COVALENT MENIN INHIBITORS<br/>[FR] COMPOSÉS PIPÉRIDINE EN TANT QU'INHIBITEURS COVALENTS DE LA MÉNINE
  申请人：UNIV MICHIGAN REGENTS

  公开号：WO2019191526A1

  公开（公告）日：2019-10-03

  The present disclosure provides compounds represented by Formula I: and the pharmaceutically acceptable salts and solvates thereof, wherein R1a, R1b, R1c, R1d, R1e, R2, R3, R8a, R8b, L, X, Z1, and Z2 are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I for use to treat a condition or disorder responsive to menin inhibition such as cancer.