2-dipiperonylamino-ethanol | 39961-59-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: 2-dipiperonylamino-ethanol
• 英文别名: 2-Dipiperonylamino-aethanol；2-Dipiperonylaminoethanol；2-[bis(1,3-benzodioxol-5-ylmethyl)amino]ethanol
• CAS: 39961-59-6
• 化学式: C₁₈H₁₉NO₅
• 分子量: 329.353
• InChiKey: MGIZPPBLEKKZPZ-UHFFFAOYSA-N

物化性质

• 沸点：
  477.7±40.0 °C(Predicted)
• 密度：
  1.354±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  60.4
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  bis(3,4-methylenedioxybenzyl)amine 、 2-氯乙醇 生成 2-dipiperonylamino-ethanol
  参考文献：
  名称：

  US2574620

  摘要：

  公开号：

文献信息

• CONTROLLED RELEASE PHARMACEUTICAL COMPOSITIONS FOR PROLONGED EFFECT
  申请人：Hemmingsen Pernille Hoyrup

  公开号：US20100239667A1

  公开（公告）日：2010-09-23

  Layered pharmaceutical composition suitable for oral use in the treatment of diseases where absorption takes place over a large part of the gastrointestinal tract. The composition comprising A) a solid inner layer comprising i) an active substance, and ii) one or more disintegrants/exploding agents, one of more effervescent agents or a mixture thereof. the solid inner layer being sandwiched between two outer layers B1) and B2), each outer layer comprising iii) a substantially water soluble and/or crystalline polymer or a mixture of substantially water soluble and/or crystalline polymers, the polymer being a polyglycol in the form of one of a) a homopolymer having a MW of at least about 100,000 daltons, and b) a copolymer having a MW of at least about 2,000 daltons, or a mixture thereof, and iv) an active substance, which is the same as in said solid inner layer A), and layer A being different from layer B, the layered composition being coated with a coating C) that has at least one opening exposing at least one surface of said outer layer, the coating being substantially insoluble in and impermeable to fluids and comprising a polymer, and the composition having a cylindrical form optionally with one or more tapered ends, wherein the ratio between the surface area of one end surface of the cylinder and the length of the cylinder is in a range of from 0.02 to 45 mm.

  分层制药组合物，适用于口服治疗吸收发生在胃肠道大部分的疾病。该组合物包括A) 一个固体内层，其中包括i) 一种活性物质，和ii) 一种或多种分散剂/爆炸剂，一种或多种泡腾剂或其混合物。该固体内层被夹在两个外层B1)和B2)之间，每个外层包括iii) 一种或多种水溶性和/或结晶聚合物，或者水溶性和/或结晶聚合物的混合物，聚合物为聚乙二醇，形式为a) 分子量至少为约100,000道尔顿的同聚物，和b) 分子量至少为约2,000道尔顿的共聚物，或其混合物，和iv) 一种活性物质，其与所述固体内层A)中的活性物质相同，且层A与层B不同，该分层组合物被涂覆有一种涂层C)，该涂层具有至少一个开口，暴露出至少一个外层的表面，该涂层在液体中具有相当的不溶性和不透性，包括一种聚合物，该组合物具有圆柱形状，可选地具有一个或多个锥形端部，其中圆柱体的一个端面的表面积与圆柱体的长度之比在0.02至45毫米的范围内。
• Controlled release formulation with continuous efficacy
  申请人：Egalet Ltd.

  公开号：EP2700400A1

  公开（公告）日：2014-02-26

  The present invention relates to pharmaceutical compositions, which provide controlled release of a drug. The compositions are suitable for continuous administration as they remain effective throughout the treatment regimen. The present invention also relates to the use of the compositions for preparation of a medicament for continuous treatment of an individual.

  本发明涉及可控制药物释放的药物组合物。这些组合物适合连续给药，因为它们在整个治疗过程中都能保持有效。本发明还涉及使用这些组合物制备用于对个人进行连续治疗的药物。
• Pharmaceutical compositions resistant to abuse
  申请人：Egalet Ltd.

  公开号：US10105321B2

  公开（公告）日：2018-10-23

  The present invention provides immediate release pharmaceutical compositions for oral administration that are resistant to abuse.

  本发明提供了抗滥用的口服速释药物组合物。
• Abuse-deterrent controlled release formulations
  申请人：PATHEON SOFTGELS INC.

  公开号：US10182992B2

  公开（公告）日：2019-01-22

  Described herein are abuse deterrent controlled release oral pharmaceutical compositions comprising and methods for making the same. In particular, an abuse deterrent controlled release oral pharmaceutical composition comprising a soft capsule and an abuse deterrent controlled release matrix comprising an active pharmaceutical ingredient are described.

  本文描述的是由阻断药物滥用的控释口服药物组合物及其制造方法。特别是描述了一种包含软胶囊和包含活性药物成分的滥用威慑控释基质的滥用威慑控释口服药物组合物。
• Enteric soft capsule compositions
  申请人：PATHEON SOFTGELS INC.

  公开号：US10226432B2

  公开（公告）日：2019-03-12

  Described herein are enteric soft capsules comprising gastric resistant polymers and gelatin and methods for manufacturing the same. The enteric soft capsules described herein have enhanced enteric and elastic properties and are simpler to manufacture and produce.

  本文描述了由抗胃聚合物和明胶组成的肠溶软胶囊及其制造方法。本文所述的肠溶软胶囊具有更强的肠道和弹性特性，并且更易于制造和生产。