12-Anthracen-1-yloxyoctadec-9-enoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 12-Anthracen-1-yloxyoctadec-9-enoic acid
• 英文别名: 12-anthracen-1-yloxyoctadec-9-enoic acid
• 化学式: C₃₂H₄₂O₃
• 分子量: 474.7
• InChiKey: LSNCFAMYZIDMHU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.6
• 重原子数：
  35
• 可旋转键数：
  17
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Inhibitors of fatty acid oxidation for prophylaxis and treatment of diseases related to mitochondrial dysfunction
  申请人：Henkel Thomas

  公开号：US20100034796A1

  公开（公告）日：2010-02-11

  Described are a method and a composition for preventing and/or treating a disease related to mitochondrial dysfunction by inhibiting the fatty acid oxidation of one or more cells of an organism. Particularly, the fatty acid oxidation is inhibited by inhibiting the expression and/or activity of the enzyme Carnitin-Palmitoyl-Transferase- 1 (CPT- 1 ) by means of an arylalkyl- or arlyoxyalkyl-substitued oxirane carboxylic acid or pharmaceutically acceptable salts and derivatives of the arylalkyl-substituted oxirane carboxylic acid.