bis(trimethylsilyl) α-phenylaminobenzylphosphonite | 93593-97-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: bis(trimethylsilyl) α-phenylaminobenzylphosphonite
• 英文别名: bis(trimethylsilyl) (α-anilinobenzyl)phosphonite；N-[bis(trimethylsilyloxy)phosphanyl-phenylmethyl]aniline
• CAS: 93593-97-6
• 化学式: C₁₉H₃₀NO₂PSi₂
• 分子量: 391.597
• InChiKey: NFQBSEGYJJYAJU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.81
• 重原子数：
  25
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  30.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-甲氧基苯甲醛 、 bis(trimethylsilyl) α-phenylaminobenzylphosphonite 以 苯 、 乙醇 为溶剂， 反应 3.0h， 以1.1 g的产率得到α-(phenylamino)benzyl(α-hydroxy-p-methoxybenzyl)phosphinic acid
  参考文献：
  名称：

  A Method for Preparing Phosphinic Acids from Hypophosphites: III. Synthesis of α-Hydroxy Phosphinic Acids

  摘要：

  A one-pot method is proposed for preparing unsymmetrical alpha-hydroxy phosphinic acids from ammonium hypophosphite. Bis(trimethylsilyl) phosphonites formed in situ on addition of bis(trimethylsilyl) hypophosphite to activated unsaturated compounds are brought without isolation into the Abramov reaction with an aldehyde or ketone. A series of new alpha-hydroxy phosphinic acids are obtained.

  DOI：

  10.1023/b:rugc.0000045869.52822.6f
• 作为产物：
  描述：

  六甲基二硅氮烷 在 次磷酸铵 作用下， 以 苯 为溶剂， 反应 4.5h， 生成 bis(trimethylsilyl) α-phenylaminobenzylphosphonite
  参考文献：
  名称：

  A Method for Preparing Phosphinic Acids from Hypophosphites: III. Synthesis of α-Hydroxy Phosphinic Acids

  摘要：

  A one-pot method is proposed for preparing unsymmetrical alpha-hydroxy phosphinic acids from ammonium hypophosphite. Bis(trimethylsilyl) phosphonites formed in situ on addition of bis(trimethylsilyl) hypophosphite to activated unsaturated compounds are brought without isolation into the Abramov reaction with an aldehyde or ketone. A series of new alpha-hydroxy phosphinic acids are obtained.

  DOI：

  10.1023/b:rugc.0000045869.52822.6f

文献信息

• Romanov, G. V.; Nazmutdinov, R. Ya.; Ryzhikova, T. Ya., Journal of general chemistry of the USSR, 1984, vol. 54, # 8, p. 1559 - 1563
  作者：Romanov, G. V.、Nazmutdinov, R. Ya.、Ryzhikova, T. Ya.、Gryaznova, T. V.、Pudovik, A. N.

  DOI：——

  日期：——
• Pudovik, A. N.; Khairullin, V. K.; Saakyan, G. M., Russian Journal of General Chemistry, 1999, vol. 69, # 1, p. 23 - 25
  作者：Pudovik, A. N.、Khairullin, V. K.、Saakyan, G. M.、Shagidullin, R. R.、Pudovik, M. A.、Vandyukova, I. I.、Musin, R. Z.

  DOI：——

  日期：——
• POMAHOB, G. V.;NAZMUTDINOV, R. YA.;RYZHIKOVA, T. YA.;GRYAZNOVA, T. V.;PUD+, ZH. OBSHCH. XIMII, 1984, 54, N 8, 1749-1754
  作者：POMAHOB, G. V.、NAZMUTDINOV, R. YA.、RYZHIKOVA, T. YA.、GRYAZNOVA, T. V.、PUD+

  DOI：——

  日期：——
• A Method for Preparing Phosphinic Acids from Hypophosphites: III. Synthesis of α-Hydroxy Phosphinic Acids
  作者：L. F. Rozhko、V. V. Ragulin

  DOI：10.1023/b:rugc.0000045869.52822.6f

  日期：2004.7

  A one-pot method is proposed for preparing unsymmetrical alpha-hydroxy phosphinic acids from ammonium hypophosphite. Bis(trimethylsilyl) phosphonites formed in situ on addition of bis(trimethylsilyl) hypophosphite to activated unsaturated compounds are brought without isolation into the Abramov reaction with an aldehyde or ketone. A series of new alpha-hydroxy phosphinic acids are obtained.