8-methyl-1-phenyl-2,3,4,9-tetrahydro-1H-β-carboline | 865681-23-8

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 哈马拉生物碱
• 英文名称: 8-methyl-1-phenyl-2,3,4,9-tetrahydro-1H-β-carboline
• 英文别名: 8-methyl-1-phenyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
• CAS: 865681-23-8
• 化学式: C₁₈H₁₈N₂
• 分子量: 262.354
• InChiKey: HUTPLCWVGWVWKS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  27.8
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  7-甲基色胺 、 苯甲醛 在 1-丙基磷酸酐 作用下， 以 乙酸乙酯 为溶剂， 反应 0.17h， 以95%的产率得到8-methyl-1-phenyl-2,3,4,9-tetrahydro-1H-β-carboline
  参考文献：
  名称：

  A facile and efficient synthesis of tetrahydro-β-carbolines

  摘要：

  This Letter describes a convenient, efficient, and clean synthesis of various tetrahydro-beta-carbolines catalyzed by propane phosphonic acid anhydride T3P (R) under microwave irradiation. (c) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.04.107

文献信息

• ADMINISTRATION OF CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISEASES
  申请人：Cao Liangxian

  公开号：US20070254878A1

  公开（公告）日：2007-11-01

  In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and compositions, and methods for the administration and use of those compounds. provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the treatment of solid tumor cancer, and in reducing serum, plasma, and/or tumor VEGF levels, are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the treatment of cancer, and the reduction of plasma and/or tumor VEGF levels, using the compounds of the invention.

  根据本发明，已经鉴定出了抑制VEGF在转录后表达的化合物，以及这些化合物的组合物、管理和使用方法。在发明的一个方面，提供了在抑制VEGF生产、治疗实体肿瘤癌和减少血清、血浆和/或肿瘤VEGF水平方面有用的化合物。在发明的另一个方面，提供了使用本发明的化合物抑制VEGF生产、治疗癌症和减少血浆和/或肿瘤VEGF水平的方法。
• Carboline Derivatives Useful in the Inhibition of Angiogenesis
  申请人：MOON Young-Choon

  公开号：US20070281962A2

  公开（公告）日：2007-12-06

  In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the inhibition of angiogenesis, and/or in the treatment of cancer, diabetic retinopathy or exudative macular degeneration are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the inhibition of angiogenesis, and/or the treatment of cancer, diabetic retinopathy or exudative macular degeneration using the compounds of the invention.

  根据本发明，已经鉴定出了抑制VEGF转录后表达的化合物，并提供了它们的使用方法。在本发明的一个方面，提供了在抑制VEGF产生、抑制血管生成和/或治疗癌症、糖尿病视网膜病变或渗出性黄斑变性方面有用的化合物。在本发明的另一个方面，提供了使用本发明中的化合物抑制VEGF产生、抑制血管生成和/或治疗癌症、糖尿病视网膜病变或渗出性黄斑变性的方法。
• CARBOLINE DERIVATIVES USEFUL IN THE INHIBITION OF ANGIOGENESIS
  申请人：MOON Young-Choon

  公开号：US20110160190A1

  公开（公告）日：2011-06-30

  In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the treatment of solid tumor cancer, and in reducing plasma and/or tumor VEGF levels, are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the treatment of cancer, and the reduction of plasma and/or tumor VEGF levels, using the compounds of the invention.

  根据本发明，已经确定了抑制VEGF在转录后表达的化合物，并提供了其使用方法。在本发明的一个方面中，提供了用于抑制VEGF产生、治疗实体肿瘤癌和降低血浆和/或肿瘤VEGF水平的化合物。在本发明的另一个方面中，提供了使用本发明的化合物抑制VEGF产生、治疗癌症和降低血浆和/或肿瘤VEGF水平的方法。
• CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISEASES
  申请人：Cao Liangxian

  公开号：US20120129841A1

  公开（公告）日：2012-05-24

  In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and compositions, and methods for the administration and use of those compounds. provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the treatment of solid tumor cancer, and in reducing serum, plasma, and/or tumor VEGF levels, are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the treatment of cancer, and the reduction of plasma and/or tumor VEGF levels, using the compounds of the invention.

  根据本发明，已经鉴定出抑制VEGF转录后表达的化合物，以及这些化合物的组合物、用于管理和使用这些化合物的方法。在本发明的一个方面，提供了在抑制VEGF产生、治疗实体肿瘤癌和减少血清、血浆和/或肿瘤VEGF水平方面有用的化合物。在本发明的另一个方面，提供了使用本发明的化合物抑制VEGF产生、治疗癌症和减少血浆和/或肿瘤VEGF水平的方法。
• Carboline derivatives useful in the treatment of cancer
  申请人：PTC Therapeutics, Inc.

  公开号：EP2298304A2

  公开（公告）日：2011-03-23

  In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the treatment of solid tumor cancer, and in reducing plasma and/or tumor VEGF levels, are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the treatment of cancer, and the reduction of plasma and/or tumor VEGF levels, using the compounds of the invention.

  根据本发明，已鉴定出转录后抑制血管内皮生长因子表达的化合物，并提供了使用这些化合物的方法。在本发明的一个方面，提供了用于抑制血管内皮生长因子产生、治疗实体瘤癌症以及降低血浆和/或肿瘤血管内皮生长因子水平的化合物。在本发明的另一方面，提供了使用本发明化合物抑制 VEGF 生成、治疗癌症以及降低血浆和/或肿瘤 VEGF 水平的方法。