4-(5-Chlorofuran-2-yl)-2,6-di(thiophen-3-yl)pyridine | 1207610-68-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-(5-Chlorofuran-2-yl)-2,6-di(thiophen-3-yl)pyridine
• CAS: 1207610-68-1
• 化学式: C₁₇H₁₀ClNOS₂
• 分子量: 343.857
• InChiKey: AVYUEYJKXMWWFZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  82.5
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-[2-氧代-2-(噻吩-3-基)乙基]吡啶碘化物 、 3-(5-chlorofuran-2-yl)-1-(thiophen-3-yl)-propenone 在 ammonium acetate 作用下， 以 甲醇 为溶剂， 生成 4-(5-Chlorofuran-2-yl)-2,6-di(thiophen-3-yl)pyridine
  参考文献：
  名称：

  2,6-Dithienyl-4-furyl pyridines: Synthesis, topoisomerase I and II inhibition, cytotoxicity, structure–activity relationship, and docking study

  摘要：

  For the development of novel antitumor agents, 2,6-dithienyl-4-furyl pyridine derivatives were prepared and evaluated for their topoisomerase I and II inhibitory activity as well as cytotoxicity against several human cancer cell lines. Among the 21 prepared compounds, compound 24 exhibited strong topoisomerase I inhibitory activity. In addition, a docking study with topoisomerase I and compound 24 was performed. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.11.041

文献信息

• 2,6-Dithienyl-4-furyl pyridines: Synthesis, topoisomerase I and II inhibition, cytotoxicity, structure–activity relationship, and docking study
  作者：Arjun Basnet、Pritam Thapa、Radha Karki、Hoyoung Choi、Jae Hun Choi、Minho Yun、Byeong-Seon Jeong、Yurngdong Jahng、Younghwa Na、Won-Jea Cho、Youngjoo Kwon、Chong-Soon Lee、Eung-Seok Lee

  DOI：10.1016/j.bmcl.2009.11.041

  日期：2010.1

  For the development of novel antitumor agents, 2,6-dithienyl-4-furyl pyridine derivatives were prepared and evaluated for their topoisomerase I and II inhibitory activity as well as cytotoxicity against several human cancer cell lines. Among the 21 prepared compounds, compound 24 exhibited strong topoisomerase I inhibitory activity. In addition, a docking study with topoisomerase I and compound 24 was performed. (C) 2009 Elsevier Ltd. All rights reserved.