[Azido(phenyl)methyl] carbamate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [Azido(phenyl)methyl] carbamate
• 英文别名: [azido(phenyl)methyl] carbamate
• 化学式: C8H8N4O2
• 分子量: 192.17
• InChiKey: UFGOWJKQGXWHCY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  66.7
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Staudinger Reaction in Imaging and Therapy and Kits for Use in Imaging and Therapy
  申请人：Robillard Marc Stefan

  公开号：US20080274057A1

  公开（公告）日：2008-11-06

  The Staudinger reaction can be used for activation of prodrugs or pro-imaging probes. The invention relates to a method of preparing and activating prodrugs or pro-imaging probes by using the Staudinger reaction and to kits for medical imaging and/or therapy comprising at least one prodrug and/or pro-imaging probe comprising at least one azide and/or phosphine group.

  Staudinger反应可用于激活前药或前成像探针。该发明涉及一种利用Staudinger反应制备和激活前药或前成像探针的方法，以及包括至少一种含有叠氮基团和/或膦基团的前药和/或前成像探针的医学成像和/或治疗套件。
• THE STAUDINGER REACTION IN IMAGING AND THERAPY AND KITS FOR USE IN IMAGING AND THERAPY
  申请人：Koninklijke Philips Electronics N.V.

  公开号：EP1986700A2

  公开（公告）日：2008-11-05
• [EN] THE STAUDINGER REACTION IN IMAGING AND THERAPY AND KITS FOR USE IN IMAGING AND THERAPY<br/>[FR] REACTION DE STAUDINGER UTILISEE EN IMAGERIE ET EN THERAPIE ET KITS A UTILISER EN IMAGERIE ET EN THERAPIE
  申请人：KONINKL PHILIPS ELECTRONICS NV

  公开号：WO2007039864A2

  公开（公告）日：2007-04-12

  [EN] The Staudinger reaction can be used for activation of prodrugs or pro-imaging probes. The invention relates to a method of preparing and activating prodrugs or pro-imaging probes by using the Staudinger reaction and to kits for medical imaging and/or therapy comprising at least one prodrug and/or pro-imaging probe comprising at least one azide and/or phosphine group.
  [FR] Selon l'invention, la réaction de Staudinger peut être utilisée pour l'activation de promédicaments ou de sondes de pro-imagerie. L'invention concerne un procédé de préparation et d'activation de promédicaments ou de sondes de pro-imagerie au moyen de la réaction de Staudinger ainsi que des kits d'imagerie médicale et/ou de thérapie comprenant au moins un promédicament et/ou une sonde de pro-imagerie contenant au moins un groupe azide et/ou un groupe phosphine.