4-<4-(4-Methoxyphenoxy)benzyl>heptan-3,5-dion | 67206-00-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-<4-(4-Methoxyphenoxy)benzyl>heptan-3,5-dion
• 英文别名: 4-[4-(4-Methoxyphenoxy)benzyl]heptane-3,5-dione；4-[[4-(4-Methoxyphenoxy)phenyl]methyl]heptane-3,5-dione
• CAS: 67206-00-2
• 化学式: C₂₁H₂₄O₄
• 分子量: 340.419
• InChiKey: CNRQLKZADXQEDI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  25
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-(bromomethyl)-4-(4-methoxyphenoxy)benzene 以57%的产率得到
  参考文献：
  名称：

  DIANA G. D.; CARABATEAS P. M.; JOHNSON R. E.; WILLIAMS G. L.; PANCIC F.; +, J. MED. CHEM., 1978, 21, NO 9, 889-894

  摘要：

  DOI：

文献信息

• Antiviral activity of some .beta.-diketones. 4. Benzyl diketones. In vitro activity against both RNA and DNA viruses
  作者：G. D. Diana、Philip M. Carabateas、Robert E. Johnson、Gordon L. Williams、Francis Pancic、Joseph C. Collins

  DOI：10.1021/jm00207a010

  日期：1978.9

  The synthesis and in vitro antiviral evaluation of a series of substituted benzyl beta-diketones are described. The introduction of a styryl group onto the phenyl ring enhanced activity against herpesvirus type 2. The 4-methoxystyryl homologue 8 was evaluated extensively in vitro and was found to be effective against both RNA and DNA viruses. Compound 8 was evaluated in the mouse vagina against herpes simplex type 1 and produced a significant increase in survival rate as well as in survival time.
• US4153719A
  申请人：——

  公开号：US4153719A

  公开（公告）日：1979-05-08
• DIANA G. D.; CARABATEAS P. M.; JOHNSON R. E.; WILLIAMS G. L.; PANCIC F.; +, J. MED. CHEM., 1978, 21, NO 9, 889-894
  作者：DIANA G. D.、 CARABATEAS P. M.、 JOHNSON R. E.、 WILLIAMS G. L.、 PANCIC F.、 +

  DOI：——

  日期：——