[2-(1-{3-[4-(tert-butoxycarbonylamino-methyl)-phenoxy]-5-[4-(N-hydroxy-carbamimidoyl)-phenoxy]-benzoyl}-piperidin-4-yl)-ethyl]-carbamic acid tert-butyl ester | 1256596-63-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [2-(1-{3-[4-(tert-butoxycarbonylamino-methyl)-phenoxy]-5-[4-(N-hydroxy-carbamimidoyl)-phenoxy]-benzoyl}-piperidin-4-yl)-ethyl]-carbamic acid tert-butyl ester
• 英文别名: tert-butyl N-[[4-[3-[4-(N'-hydroxycarbamimidoyl)phenoxy]-5-[4-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethyl]piperidine-1-carbonyl]phenoxy]phenyl]methyl]carbamate
• CAS: 1256596-63-0
• 化学式: C₃₈H₄₉N₅O₈
• 分子量: 703.836
• InChiKey: RINRRAAVKHNHRD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  51
• 可旋转键数：
  15
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  174
• 氢给体数：
  4
• 氢受体数：
  9

文献信息

• PROTEASE INHIBITORS
  申请人：Goswami Rajeev

  公开号：US20120136002A1

  公开（公告）日：2012-05-31

  A compound of formula (I) wherein R 1 to R 15 , P 1 , P 2 , A, B and Q are as defined in the claims and pharmaceutically acceptable salts and esters thereof, are disclosed. The compounds of formula (I) possess utility as matriptase inhibitors and are useful in the treatment of matriptase dependent conditions, particularly cancer.

  公式（I）的化合物中，其中R1至R15、P1、P2、A、B和Q的定义如索赔中所述，并披露其药用盐和酯。公式（I）的化合物具有作为matriptase抑制剂的效用，并在治疗matriptase依赖性疾病，特别是癌症方面是有用的。
• US8722930B2
  申请人：——

  公开号：US8722930B2

  公开（公告）日：2014-05-13
• [EN] PROTEASE INHIBITORS<br/>[FR] INHIBITEURS DE PROTÉASE
  申请人：ORION CORP

  公开号：WO2010133748A1

  公开（公告）日：2010-11-25

  A compound of formula (I) wherein R1 to R15, P1, P2, A, B and Q are as defined in the claims and pharmaceutically acceptable salts and esters thereof, are disclosed. The compounds of formula (I) possess utility as matriptase inhibitors and are useful in the treatment of matriptase dependent conditions, particularly cancer.