6-Methyl-3-phenyl-2,3,4,5-tetrahydropyridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 6-Methyl-3-phenyl-2,3,4,5-tetrahydropyridine
• 英文别名: 6-methyl-3-phenyl-2,3,4,5-tetrahydropyridine
• 化学式: C₁₂H₁₅N
• 分子量: 173.25
• InChiKey: QNDBXSMLLQXAIQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  12.4
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• [EN] INHIBITING OTUB1<br/>[FR] INHIBITION DE L'OTUB1
  申请人：INTEGRAL EARLY DISCOVERY INC

  公开号：WO2020223551A1

  公开（公告）日：2020-11-05

  The present disclosure is directed to compounds of formulas (I) - (VII), which are useful as modulators of OTUB1. The compounds are further useful in the inhibition of OTUB1 and the treatment of diseases or disorders associated with the inhibition of OTUB1. For instance, the disclosure is concerned with compounds and compositions for inhibition of OTUB1, methods of treating diseases associated with the inhibition of OTUB1 (e.g., inflammatory diseases like irritable bowel disease and Lupus), and methods of synthesis of these compounds.

  本公开涉及的是公式(I)-(VII)的化合物，它们可用作OTUB1的调节剂。这些化合物还可用于抑制OTUB1和治疗与抑制OTUB1相关的疾病或疾病。例如，本公开涉及用于抑制OTUB1的化合物和组合物，治疗与抑制OTUB1相关的疾病的方法（例如，炎症性疾病，如肠易激综合征和红斑狼疮），以及这些化合物的合成方法。