sodium 2-(dimethylamino)benzoate | 71371-39-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: sodium 2-(dimethylamino)benzoate
• 英文别名: N,N-dimethyl-anthranilic acid ; sodium-compound；N,N-Dimethyl-anthranilsaeure; Natrium-Verbindung；Sodium;2-(dimethylamino)benzoate
• CAS: 71371-39-6
• 化学式: C₉H₁₀NO₂*Na
• 分子量: 187.174
• InChiKey: MYQVDEFXUTZYFL-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -2.88
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  、 sodium 2-(dimethylamino)benzoate 以 乙腈 为溶剂， 生成 C78H62Mn6N4O22
  参考文献：
  名称：

  [Mn6O2{O2C-3,5-(NO2)2-C6H3}10(C5H5N)2{(CH3)2CO}2].2(CH3)2CO.2(C2H5)2O and [Mn6O2(O2CC6H5)10(NCCH3)4]

  摘要：

  The structures of di(acetone)tetrakis(mu(3)-3,5-dinitrobenzoato-kappa(2)O:kappa O')hexakis(mu-3,5-dinitrobenzoato-kappa O:-kappa O')-di-mu 4-oxo-di(pyridine)tetramanganenese(II)dimanganese(III)-acetone-diethyl ether (1/2/2), (1), and tetrakis(acetonitrile)tetrakis(mu(3)-benzoato-kappa(2)O:kappa O')hexakis-(mu-benzoato-kappa O:kappa O')-di-mu(4)-oxo-tetramanganese(II)dimanganese(III), (2), are reported. Both compounds contain six octahedrally coordinated Mn centres, arranged as two (Mn2Mn2III)-Mn-II (mu(4)-O) tetrahedra sharing the Mn-III-Mn-III edge.

  DOI：

  10.1107/s0108270194013764
• 作为产物：
  描述：

  2-二甲基氨基苯甲酸 在 sodium hydroxide 作用下， 以 甲醇 、 水 为溶剂， 以90%的产率得到sodium 2-(dimethylamino)benzoate
  参考文献：
  名称：

  复杂的多杂环和 Pileamartine A 通过 Aza-Heck 触发的芳基 C-H 官能化级联的立体化学重新分配

  摘要：

  结构复杂的苯并和螺融合的 N-多杂环可以通过分子内 Pd(0)-催化的烯烃 1,2-氨基芳基化反应获得。该方法使用N -（五氟苯甲酰氧基）氨基甲酸酯作为起始基序，这允许在芳烃组分的 C-H 钯化之前进行 aza-Heck 型烯烃氨基化。这种化学反应在复杂生物碱 (+)-pileamartine A 的首次全合成中得到了展示，这导致了其绝对立体化学的重新分配。

  DOI：

  10.1021/jacs.1c08615

文献信息

• Method and reagent composition for the determination of alanine aminotransferase and HBsAg antigen in the same biological specimen
  申请人：SCLAVO S.p.A.

  公开号：EP0457214A2

  公开（公告）日：1991-11-21

  The enzyme alanine aminotransferase (ALT) is colorimetrically determined as the hydrogen peroxide obtained in the pyruvate hydrolysis reaction catalysed by the enzyme pyruvate oxidase which develops a colour read at 550 nm making use of a reagent composition buffered at pH comprised within 7.0 and 7.5 containing L-alanine, ketoglutaric acid, a source of inorganic phosphorous, the enzyme pyruvate oxidase, a system for revealing the hydrogen peroxide and optionally one or more co-factors which interact in the enzymatic reaction catalysed by the enzyme pyruvate oxidase. It is moreover described a method for the determination of the enzyme alanine aminotransferase making use of said reagent composition and of the surface antigen of the hepatitis B virus (HBsAg), by enzymeimmune assay, in the same serum specimen and in the same well of a microtitration plate. The method is particularly useful for checking the suitability of the blood intended for transfusions since it can be easily carried out with equipments and instruments widely used for the immunoenzymatic screening of infectivity. Furthermore it enables to test in the same analytical assay the two labels of hepatocyte infections necessarily researched in the transfusion centres on biological specimens and to select among the donors the most likely candidates to transmission of the NANB hepatitis virus.

  丙氨酸氨基转移酶（ALT）是通过丙酮酸氧化酶催化的丙酮酸水解反应中产生的过氧化氢进行比色测定的，过氧化氢在 550 纳米波长处显色。该方法利用 pH 值在 7.0 和 7.5 之间的缓冲试剂组合物，其中含有 L-丙氨酸、酮戊二酸、无机磷源、丙酮酸氧化酶、过氧化氢显现系统以及在丙酮酸氧化酶催化的酶促反应中相互作用的一种或多种辅助因子。此外，还描述了一种测定丙氨酸氨基转移酶的方法，该方法利用所述试剂组合物和乙型肝炎病毒表面抗原（HBsAg），通过酶免疫测定法，在同一血清标本中和微量滴定板的同一孔中进行测定。这种方法特别适用于检查输血血液的适用性，因为它可以使用广泛用于感染性免疫酶筛查的设备和仪器轻松完成。此外，它还能在同一分析测定中检测输血中心必须对生物标本进行研究的两种肝细胞感染标签，并从献血者中筛选出最有可能传播 NANB 肝炎病毒的人。
• LATERAL FLOW AND FLOW-THROUGH BIOASSAY BASED ON PATTERNED POROUS MEDIA, METHODS OF MAKING SAME, AND METHODS OF USING SAME
  申请人：President and Fellows of Harvard College

  公开号：EP2076775B1

  公开（公告）日：2015-08-19
• Lateral Flow and Flow-through Bioassay Devices Based On Patterned Porous Media, Methods of Making Same, and Methods of Using Same
  申请人：WHITESIDES George M.

  公开号：US20090298191A1

  公开（公告）日：2009-12-03

  Embodiments of the invention provide lateral flow and flow-through bioassay devices based on patterned porous media, methods of making same, and methods of using same. Under one aspect, an assay device includes a porous, hydrophilic medium; a fluid impervious barrier comprising polymerized photoresist, the barrier substantially permeating the thickness of the porous, hydrophilic medium and defining a boundary of an assay region within the porous, hydrophilic medium; and an assay reagent in the assay region.
• Lateral Flow and Flow-through Bioassay Devices Based on Patterned Porous Media, Methods of Making Same, and Methods of Using Same
  申请人：President and Fellows of Harvard College

  公开号：US20130128036A1

  公开（公告）日：2013-05-23

  Embodiments of the invention provide lateral flow and flow-through bioassay devices based on patterned porous media, methods of making same, and methods of using same. Under one aspect, an assay device includes a porous, hydrophilic medium; a fluid impervious barrier comprising polymerized photoresist, the barrier substantially permeating the thickness of the porous, hydrophilic medium and defining a boundary of an assay region within the porous, hydrophilic medium; and an assay reagent in the assay region.
• LATERAL FLOW AND FLOW-THROUGH BIOASSAY DEVICES BASED ON PATTERNED POROUS MEDIA, METHODS OF MAKING SAME, AND METHODS OF USING SAME
  申请人：President and Fellows of Harvard College

  公开号：US20140234881A1

  公开（公告）日：2014-08-21

  Embodiments of the invention provide lateral flow and flow-through bioassay devices based on patterned porous media, methods of making same, and methods of using same. Under one aspect, an assay device includes a porous, hydrophilic medium; a fluid impervious barrier comprising polymerized photoresist, the barrier substantially permeating the thickness of the porous, hydrophilic medium and defining a boundary of an assay region within the porous, hydrophilic medium; and an assay reagent in the assay region.