N,N-dimethyl-2-[2-nitro-4-(1,1,2,2,2-pentafluoroethyl)phenyl]ethenamine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N-dimethyl-2-[2-nitro-4-(1,1,2,2,2-pentafluoroethyl)phenyl]ethenamine
• 化学式: C12H11F5N2O2
• 分子量: 310.22
• InChiKey: RUUYCLZHNNVVIJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  49.1
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• 8-Substituted Benzoazepines as Toll-Like Receptor Modulators
  申请人：Doherty George A.

  公开号：US20080234251A1

  公开（公告）日：2008-09-25

  Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in the treatment of autoimmunity, inflammation allergy, asthma, graft rejection, graft versus host disease, infection, sepsis, cancer and immunodeficiency.

  提供的是用于调节Toll样受体TLR7和/或TLR8信号传导的组合物和方法。这些组合物和方法在治疗自身免疫、炎症过敏、哮喘、移植排斥、移植物抗宿主病、感染、败血症、癌症和免疫缺陷方面有用。
• 8-SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS
  申请人：Doherty George A.

  公开号：US20120165317A1

  公开（公告）日：2012-06-28

  Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in the treatment of autoimmunity, inflammation allergy, asthma, graft rejection, graft versus host disease, infection, sepsis, cancer and immunodeficiency.

  提供了用于调节Toll样受体TLR7和/或TLR8信号传导的组合物和方法。这些组合物和方法在治疗自身免疫、炎症、过敏、哮喘、移植排斥、移植物抗宿主病、感染、败血症、癌症和免疫缺陷方面有用。
• 8-substituted benzoazepines as toll-like receptor modulators
  申请人：Array Biopharma, Inc.

  公开号：EP2322510A2

  公开（公告）日：2011-05-18

  Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8 The compositions and methods have use in the treatment of autoimmunity, inflammation allergy, asthma, graft rejection, graft versus host disease, infection, sepsis, cancer and immunodeficiency.

  所提供的组合物和方法可用于调节通过 Toll 样受体 TLR7 和/或 TLR8 发送的信号。这些组合物和方法可用于治疗自身免疫、炎症过敏、哮喘、移植物排斥、移植物抗宿主疾病、感染、败血症、癌症和免疫缺陷。
• US8153622B2
  申请人：——

  公开号：US8153622B2

  公开（公告）日：2012-04-10
• US8304407B2
  申请人：——

  公开号：US8304407B2

  公开（公告）日：2012-11-06