benzyl (3,6-dichloropyridazin-4-yl)methylcarbamate | 631914-69-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzyl (3,6-dichloropyridazin-4-yl)methylcarbamate
• 英文别名: Benzyl ((3,6-dichloropyridazin-4-yl)methyl)carbamate；benzyl N-[(3,6-dichloropyridazin-4-yl)methyl]carbamate
• CAS: 631914-69-7
• 化学式: C₁₃H₁₁Cl₂N₃O₂
• 分子量: 312.155
• InChiKey: JERNOWDJNHADOW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  64.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3,6-二氯哒嗪 、 N-苄氧羰基甘氨酸 在 ammonium persulfate 、 silver nitrate 、 三氟乙酸 作用下， 以 水 为溶剂， 以81%的产率得到benzyl (3,6-dichloropyridazin-4-yl)methylcarbamate
  参考文献：
  名称：

  Use of N-Protected Amino Acids in the Minisci Radical Alkylation

  摘要：

  The Minisci radical alkylation has been demonstrated on a range of commercially available glycine derivatives and proceeds in good to high yield. When extending the reaction to other amino acids, competitive oxidation of the initially formed radical was overcome by using the phthalimide protecting group.

  DOI：

  10.1021/ol035814+

文献信息

• Use of N-Protected Amino Acids in the Minisci Radical Alkylation
  作者：Cameron J. Cowden

  DOI：10.1021/ol035814+

  日期：2003.11.1

  The Minisci radical alkylation has been demonstrated on a range of commercially available glycine derivatives and proceeds in good to high yield. When extending the reaction to other amino acids, competitive oxidation of the initially formed radical was overcome by using the phthalimide protecting group.