N-(4-phenylphenyl)-2-pyridin-4-ylacetamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-phenylphenyl)-2-pyridin-4-ylacetamide
• 化学式: C₁₉H₁₆N₂O
• 分子量: 288.349
• InChiKey: COWCVGVSBRLVFN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  42
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] SMALL MOLECULE ACTIVATORS OF PARKIN ENZYME FUNCTION<br/>[FR] ACTIVATEURS DE PETITES MOLÉCULES DE LA FONCTION ENZYMATIQUE DE LA PARKINE
  申请人：MAYO FOUND MEDICAL EDUCATION & RES

  公开号：WO2018023029A1

  公开（公告）日：2018-02-01

  The present disclosure relates to compounds for activating the enzymatic activity of an E3 ubiquitin ligase and methods for treating a disease or disorder in a subject with diminished E3 ubiquitin ligase enzymatic activity. In some embodiments, the present disclosure provides a compound of Formula (I) or a compound of Formula (II) or pharmaceutically acceptable salts thereof.

  本公开涉及用于激活E3泛素连接酶酶活性的化合物以及用于治疗酶活性减弱的E3泛素连接酶的疾病或障碍的方法。在某些实施例中，本公开提供公式（I）的化合物或公式（II）的化合物或其药学上可接受的盐。
• Small Molecule Activators of Parkin Enzyme Function
  申请人：Mayo Foundation for Medical Education and Research

  公开号：US20190169158A1

  公开（公告）日：2019-06-06

  The present disclosure relates to compounds for activating the enzymatic activity of an E3 ubiquitin ligase and methods for treating a disease or disorder in a subject with diminished E3 ubiquitin ligase enzymatic activity. In some embodiments, the present disclosure provides a compound of Formula (I) or a compound of Formula (II) or pharmaceutically acceptable salts thereof.