1-[(4-tert-butylphenyl)methyl]-4-[(S)-(4-chlorophenyl)-phenylmethyl]piperazine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-[(4-tert-butylphenyl)methyl]-4-[(S)-(4-chlorophenyl)-phenylmethyl]piperazine
• 化学式: C₂₈H₃₃ClN₂
• 分子量: 433.0
• InChiKey: MOYGZHXDRJNJEP-MHZLTWQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• HETEROCYCLIC COMPOUNDS AS EPHA4 INHIBITORS
  申请人：The Hong Kong University of Science and Technology

  公开号：US20200206220A1

  公开（公告）日：2020-07-02

  New methods and kits for treating diseases caused or exacerbated by overactivated EphA4 signaling are provided. The method includes administering to a subject in need thereof an effective amount of a small molecule compound inhibitor for EphA4 signaling. Also provided are methods for identifying additional compounds as therapeutic agents useful for treating conditions involving overly active EphA4 signaling.