1-Ethyl-2-fluoro-3-methylsulfanylbenzene

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 1-Ethyl-2-fluoro-3-methylsulfanylbenzene
• 英文别名: 1-ethyl-2-fluoro-3-methylsulfanylbenzene
• 化学式: C₉H₁₁FS
• 分子量: 170.25
• InChiKey: YWUWBQJQRFROPA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  25.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVE REGULATOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
  申请人：SHANGHAI HANSOH BIOMEDICAL CO., LTD.

  公开号：US20220213100A1

  公开（公告）日：2022-07-07

  Disclosed are a nitrogen-containing heterocyclic derivative regulator, a preparation method therefor and an application thereof. In particular, disclosed are a compound as represented by general formula (I), a preparation method for the compound and a pharmaceutical composition containing the compound, and the use thereof as a KRAS G12C mutation inhibitor in treatment of diseases or symptoms such as leukemia, neuroblastoma, melanoma, breast cancer, lung cancer and colon cancer, wherein the definitions of substituents in general formula (I) are the same as those in the description.