4-amino-1H-benzo[g]quinazolin-2-one | 300807-96-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 4-amino-1H-benzo[g]quinazolin-2-one
• CAS: 300807-96-9
• 化学式: C₁₂H₉N₃O
• 分子量: 211.223
• InChiKey: WTMKVPGEUWXVNF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  67.5
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-pivaloyloxymethyl-4-(1,2,4-triazol-1-yl)benzo[g]quinazolin-2-one 在 ammonium hydroxide 、 氢氧化钾 作用下， 以 1,4-二氧六环 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 72.0h， 以61%的产率得到4-amino-1H-benzo[g]quinazolin-2-one
  参考文献：
  名称：

  A Novel DNA Hairpin Substrate for Bleomycin

  摘要：

  A 16-nucleotide DNA hairpin containing 4-aminobenzo[g]quinazoline-2-one 2'-deoxyribose at position 15 has been prepared and found to lack significant fluorescence, When treated with Fe(II).BLM, the hairpin was found to undergo oxidative transformation selectively at position 15. The predominant fluorescent product was characterized and quantified. The pro-fluorescent DNA hairpin was used as a substrate for 15 bleomycin congeners, and the results were compared with those obtained following cleavage of a radiolabeled DNA duplex and PAGE analysis.

  DOI：

  10.1021/ol800445x

文献信息

• A Novel DNA Hairpin Substrate for Bleomycin
  作者：Yoshitsugu Akiyama、Qian Ma、Erin Edgar、Andrei Laikhter、Sidney M. Hecht

  DOI：10.1021/ol800445x

  日期：2008.6.5

  A 16-nucleotide DNA hairpin containing 4-aminobenzo[g]quinazoline-2-one 2'-deoxyribose at position 15 has been prepared and found to lack significant fluorescence, When treated with Fe(II).BLM, the hairpin was found to undergo oxidative transformation selectively at position 15. The predominant fluorescent product was characterized and quantified. The pro-fluorescent DNA hairpin was used as a substrate for 15 bleomycin congeners, and the results were compared with those obtained following cleavage of a radiolabeled DNA duplex and PAGE analysis.