N-morpholin-4-yl-4-propyl-benzenesulfonamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-morpholin-4-yl-4-propyl-benzenesulfonamide
• 英文别名: N-morpholin-4-yl-4-propylbenzenesulfonamide
• 化学式: C₁₃H₂₀N₂O₃S
• 分子量: 284.379
• InChiKey: DZVHQNXKGLIJBJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  67
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] PHENYLSULFONAMIDE DERIVATIVES FOR USE AS 11-BETA-HYDROXYSTEROID DEHYDROGENASE INHIBITORS<br/>[FR] DERIVES DE PHENYLSULFONAMIDE UTILES EN TANT QU'INHIBITEURS DE 11-BETA-HYDROXYSTEROIDE DESHYDROGENASE
  申请人：STERIX LTD

  公开号：WO2005103023A1

  公开（公告）日：2005-11-03

  A compound having Formula (I): R1-SO2NR3-L-R2; wherein R1 is an optionally substituted phenyl ring; R2 is a heterocyclic ring; R3 is H or a hydrocarbyl group; and L is an optional acyclic linker wherein when R2 is a five­-membered aromatic heterocyclic ring, L is present. These compounds are useful as 11β-hydroxysteroid dehydrogenase inhibitors.

  具有Formula (I)的化合物：R1-SO2NR3-L-R2；其中R1是一个可选择取代的苯环；R2是一个杂环；R3是H或一个烃基团；L是一个可选的无环连接基，在R2是一个五元芳香杂环时，L存在。这些化合物可用作11β-羟基类固醇脱氢酶抑制剂。
• PHENYLSULFONAMIDE DERIVATIVES FOR USE AS 11-BETA-HYDROXYSTEROID DEHYDROGENASE INHIBITORS
  申请人：Sterix Limited

  公开号：EP1756078A1

  公开（公告）日：2007-02-28
• Phenylsulfonamide Derivatives for Use as 11-Beta-Hydroxysteroid Dehydrogenase Inhibitors
  申请人：Vicker Nigel

  公开号：US20070244108A1

  公开（公告）日：2007-10-18

  1. A compound having Formula I R 1 —SO 2 NR 3 -L-R 2 Formula I wherein R 1 is an optionally substituted phenyl ring; R 2 is a heterocyclic ring; R 3 is H or a hydrocarbyl group; and L is an optional acyclic linker wherein when R 2 is a five-membered aromatic heterocyclic ring, L is present.