8a-(3,4-dichlorophenyl)-4,6-dimethyl-3a,4,5,6,7,8-hexahydro-3H-cyclohepta[c]furan-1-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 8a-(3,4-dichlorophenyl)-4,6-dimethyl-3a,4,5,6,7,8-hexahydro-3H-cyclohepta[c]furan-1-one
• 化学式: C₁₇H₂₀Cl₂O₂
• 分子量: 327.2
• InChiKey: SZGVSDLPIFHIGS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Triple reuptake inhibitors and methods of their use
  申请人：SUNOVION PHARMACEUTICALS INC.

  公开号：US10428021B2

  公开（公告）日：2019-10-01

  Provided herein are bicyclic compounds and methods of synthesis thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders. Compounds provided herein inhibit reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine (e.g., from the synaptic cleft) and modulate one or more monoamine transporter. Pharmaceutical formulations containing the compounds are also provided.

  本文提供的是双环化合物及其合成方法。本文提供的化合物可用于治疗、预防和/或控制各种神经系统疾病。本文提供的化合物可抑制多巴胺、5-羟色胺和去甲肾上腺素等内源性单胺的再摄取（如从突触间隙），并调节一种或多种单胺转运体。还提供了含有这些化合物的药物制剂。
• TRIPLE REUPTAKE INHIBITORS AND METHODS OF THEIR USE
  申请人：SUNOVION PHARMACEUTICALS INC.

  公开号：US20180148407A1

  公开（公告）日：2018-05-31

  Provided herein are bicyclic compounds and methods of synthesis thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders. Compounds provided herein inhibit reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine (e.g., from the synaptic cleft) and modulate one or more monoamine transporter. Pharmaceutical formulations containing the compounds are also provided.