1,1'-Dichlor-dibutyl-ether | 53622-12-1

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氯化物
• 英文名称: 1,1'-Dichlor-dibutyl-ether
• 英文别名: bis-(1-chloro-butyl) ether；Bis-(1-chlor-butyl)-aether；1.1'-Dichlor-dibutylaether；1,1'-Oxybis(chlorobutane)；1-chloro-1-(1-chlorobutoxy)butane
• CAS: 53622-12-1
• 化学式: C₈H₁₆Cl₂O
• 分子量: 199.12
• InChiKey: RMGBJBITSZIYKA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  正丁醛 在 盐酸 作用下， 生成 1,1'-Dichlor-dibutyl-ether
  参考文献：
  名称：

  DE691622

  摘要：

  公开号：

文献信息

• [EN] COMPOUNDS COMPRISING CLEAVABLE LINKER AND USES THEREOF<br/>[FR] COMPOSÉS COMPRENANT UN LIEUR CLIVABLE ET LEURS UTILISATIONS
  申请人：INTOCELL INC

  公开号：WO2019008441A1

  公开（公告）日：2019-01-10

  Provided are a compound including a cleavable linker, a use thereof, and an intermediate compound for preparing the same, and more particularly, the compound including a cleavable linker of the present invention may include an active agent (for example, a drug, a toxin, a ligand, a probe for detection, etc.) having a specific function or activity, a SO2 functional group which is capable of selectively releasing the active agent, and a functional group which triggers a chemical reaction, a physicochemical reaction and/or a biological reaction by external stimulation, and may further include a ligand (for example, oligopeptide, polypeptide, antibody, etc.) having binding specificity for a desired target receptor.

  提供了一种包括可切割连接物的化合物，其用途，以及用于制备该化合物的中间体化合物，更具体地，本发明的包括可切割连接物的化合物可能包括具有特定功能或活性的活性剂（例如，药物，毒素，配体，用于检测的探针等），能够选择性释放活性剂的SO2官能团，以及通过外部刺激触发化学反应，物理化学反应和/或生物反应的官能团，并且还可以包括具有与所需靶受体结合特异性的配体（例如，寡肽，多肽，抗体等）。
• Haloalkylation of aromatic compounds
  申请人：ETHYL CORPORATION

  公开号：EP0369728A1

  公开（公告）日：1990-05-23

  The co-formation of diarylalkane by-product in the haloalkylation of an aromatic compound with an ether corre­sponding to the formula R-O-R′, wherein R is an α-halo­alkyl group containing at least two carbons and R′ is R or alkyl, is minimized by conducting the reaction with agita­tion in the presence of both hydrogen sulfate and a hydro­gen halide.

  在芳香族化合物与对应于式 R-O-R′ 的醚进行卤代烷基化反应时，通过在硫酸 氢和卤化氢存在下搅拌进行反应，可最大限度地减少二芳基烷烃副产物的共生成。
• Sulfide containing aliphatic epoxy resins
  申请人：THE DOW CHEMICAL COMPANY

  公开号：EP0367858A1

  公开（公告）日：1990-05-16

  Novel epoxy resins are prepared by dehydrohalogenating the reaction product of an epihalohydrin and a hydroxyalkyl containing polysulfide. Cured compositions prepared from the epoxy resins are also disclosed.

  新型环氧树脂是通过脱氢卤化表卤代烃和含羟基烷基的多硫化物的反应产物而制备的。还公开了由环氧树脂制备的固化组合物。
• Fluorination in tubular reactor system
  申请人：MINNESOTA MINING AND MANUFACTURING COMPANY

  公开号：EP0646557A1

  公开（公告）日：1995-04-05

  Direct fluorination of organics such as 1,8-dichlorooctane in tubular reactor system. Inert liquid containing organic feed is circulated through tubular reactor with fluorine gas for a time and at a temperature sufficient to yield fluorinated organic. Preferably, liquid and gas phases are separated from reactor product stream containing inert liquid, fluorinated organic, and any unreacted organic is recycled to turbulent mixing zone upstream of reactor in which fresh organic feed is added; and fluorine is added to recycle stream at end of mixing zone. Flow in tubular reactor is turbulent. Rate of organic feed and fluorine addition to process are independent of each other. Among process advantages are: Freon solvents not required; good control of reaction exotherm; and HF scavengers not required. Process useful for partial or complete fluorination.

  在管式反应器系统中对有机物（如 1,8-二氯辛烷）进行直接氟化。含有有机进料的惰性液体与氟气一起在管式反应器中循环，循环时间和温度足以产生氟化有机物。液相和气相最好从含有惰性液体、氟化有机物的反应器产品流中分离出来，任何未反应的有机物都被循环到反应器上游的湍流混合区，在该混合区中加入新鲜的有机物进料；氟被加入混合区末端的循环流中。管式反应器中的流体为湍流。有机进料和氟加入工艺的速度是相互独立的。该工艺的优点包括不需要氟利昂溶剂；反应放热控制良好；不需要氟化氢清除剂。该工艺适用于部分或全部氟化。
• Benzodiazepine derivatives and uses thereof
  申请人：IntoCell, Inc.

  公开号：US11084801B2

  公开（公告）日：2021-08-10

  The present disclosure provides compounds and compositions capable of extending lifespan, and methods of use thereof.

  本公开提供了能够延长寿命的化合物和组合物及其使用方法。