Structural simplification of bioactive natural products with multicomponent synthesis. 4. 4H-Pyrano-[2,3-b]naphthoquinones with anticancer activity
摘要:
4H-Pyrano-[2,3-b]naphthoquinone is a structural motif commonly found in natural products manifesting anticancer activities. As part of a program aimed at structural simplification of bioactive natural products utilizing multicomponent synthetic processes, we developed a compound library based on this heterocyclic scaffold. We found that several library members displayed low micromolar antiproliferative activity and induced apoptosis in human cancer cells. Selected compounds showed promising activity against cancer cell lines resistant to proapoptotic stimuli, demonstrating their potential in treating cancers with dismal prognoses. (c) 2012 Elsevier Ltd. All rights reserved.
monoquaternized octadecyl-1,4-diazabicyclo[2.2.2]octane bromide. The yield was good. The surfactant that was created was analyzed using techniques such as 1H NMR, 13CNMR, and Mass characterization. We analyzed the synthesized [DABCO-C18]Br salt and found that it has great surfactant properties. Its critical micelle concentration (CMC) is 1.15 mM as determined by the conductivity method and 1.0 mM by UV–Vis absorption