2,4-dimethyl-<1,1'-diphenyl>-3-methanol | 82617-33-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,4-dimethyl-<1,1'-diphenyl>-3-methanol
• 英文别名: 2,4-dimethyl-[1,1'-biphenyl]-3-methanol；2,6-dimethyl-3-phenylbenzyl alcohol；[1,1-Biphenyl]-3-methanol,2,4-dimethyl-；(2,6-dimethyl-3-phenylphenyl)methanol
• CAS: 82617-33-2
• 化学式: C₁₅H₁₆O
• 分子量: 212.291
• InChiKey: RCXSATVYZMEQIR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,4-dimethyl-<1,1'-diphenyl>-3-methanol 、 1R-顺式二氯菊酸 生成 1-[(1R,3R)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropyl]-2-(2,6-dimethyl-3-phenylphenyl)ethanone
  参考文献：
  名称：

  PLUMMER, E. L.

  摘要：

  DOI：
• 作为产物：
  描述：

  Methyl 2,6-dimethyl-3-phenylbenzoate 生成 2,4-dimethyl-<1,1'-diphenyl>-3-methanol
  参考文献：
  名称：

  PLUMMER, E. L.

  摘要：

  DOI：

文献信息

• [EN] 3-(4-BENZYLOXYPHENYL)PROPANOIC ACID DERIVATIVES<br/>[FR] DERIVES D'ACIDE 3-(4-BENZYLOXYPHENYL) PROPANOIQUE
  申请人：TAKEDA PHARMACEUTICAL

  公开号：WO2005063729A1

  公开（公告）日：2005-07-14

  The present invention provides a novel compound represented by the formula (I) wherein each symbol is as defined in the specification, a salt thereof and a prodrug thereof having a superior GPR40 receptor function modulating action, which can be used as an insulin secretagogue, an agent for the prophylaxis or treatment of diabetes and the like. They unexpectedly show superior GPR40 receptor agonist activity, and also show superior properties as a pharmaceutical product, such as stability and the like. Thus, they can be safe and useful pharmaceutical agents for the prophylaxis or treatment of GPR40 receptor related diseases in mammals.

  本发明提供了一种由公式(I)表示的新的化合物，其中每个符号如说明书中所定义，以及其盐和前药，具有优越的GPR40受体功能调节作用，可用作胰岛素分泌剂，用于预防或治疗糖尿病等的药剂。它们出人意料地显示出优越的GPR40受体激动剂活性，并且还显示出作为药物产品的优越性质，如稳定性等。因此，它们可以成为预防或治疗哺乳动物中与GPR40受体相关疾病的既安全又有用的药物。
• Acaricidal difluoroethenylcyclopropanecarboxylates
  申请人：FMC Corporation

  公开号：US04552892A1

  公开（公告）日：1985-11-12

  Difluoroethenylcyclopropanecarboxylates of the formula ##STR1## in which R is a selected biphenylmethyl, bridged biphenylmethyl or 4-phenyl-2-indanyl group, having a high level of activity against acarids are disclosed.

  揭示了具有高活性对螨虫的二氟乙烯基环丙酸酯的化学式为##STR1##，其中R是选择的联苯甲基、桥联联苯甲基或4-苯基-2-茚基基团。
• Cyclohexadiene carboxylate insecticide intermediates
  申请人：FMC Corporation

  公开号：US04486588A1

  公开（公告）日：1984-12-04

  Precursors to benzyl compounds, useful in the manufacture of pyrethroid insecticides, are prepared by regiospecific addition of an enamine to a heterocyclic diene accompanied by elimination of volatile by-products.

  在制造拟除虫菊酯类杀虫剂时，苯甲基化合物的前体通过在杂环二烯上进行区域特异性的恩酰胺加成反应，同时消除挥发性副产物而制备而成。
• Insecticidal (1,1'-biphenyl)-3-ylmethyl esters, their production and use and compositions containing them
  申请人：FMC Corporation

  公开号：EP0049977A1

  公开（公告）日：1982-04-21

  Insecticidal and acaricidal pyrethroid esters of formula residue is replaced by a hydroxy group or a leaving group readilv displaced bv carboxylate anions are also novel. in which R is one of certain substituted cyclopropyl radicals, A and B are certain halo, haloalkyl, alkyl and alkoxy radicals and a and b are 0, 1, 2, 3, 4 or 5, are novel and may be included in insecticidal and acaricidal compositions and used for killing insects and acarids. They can be in cis or trans configuration. Intermediate compounds in which the

  杀虫和杀螨剂拟除虫菊酯的式残基被羟基或羧酸阴离子取代的离去基团也是新颖的。 其中 R 是某些取代的环丙基之一，A 和 B 是某些卤代、卤代烷基、烷基和烷氧基，a 和 b 是 0、1、2、3、4 或 5，这些都是新型的，可包含在杀虫和杀螨组合物中，用于杀虫和杀螨。它们可以是顺式或反式构型。 其中
• Preparation of optically-active alpha-substituted carboxylic esters and acids
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0116914A1

  公开（公告）日：1984-08-29

  Optically-active alpha-substituted carboxylic esters are prepared by treating a non-symmetrical ketene with an alcohol in the presence of an optically-active amine catalyst. Hydrolysis of the resulting esters, yields the optically-active acid corresponding to the non-symmetrical ketene.

  光学活性α-取代羧酸酯是通过在光学活性胺催化剂存在下用醇处理非对称酮来制备的。水解生成的酯会产生与非对 称酮相对应的光学活性酸。