Benzenesulfonamide, N-(2-thienylmethyl)- | 92288-27-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Benzenesulfonamide, N-(2-thienylmethyl)-
• 英文别名: N-(thiophen-2-ylmethyl)benzenesulfonamide
• CAS: 92288-27-2
• 化学式: C₁₁H₁₁NO₂S₂
• mdl: MFCD00097924
• 分子量: 253.3
• InChiKey: CTZDYZKSKMNXAQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  82.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• N-substituted benzene sulfonamides
  申请人：Neitzel Martin

  公开号：US20050165003A1

  公开（公告）日：2005-07-28

  Disclosed are N-substituted benzenesulfonamides for use in treating or preventing cognitive disorders, such as Alzheimer's Disease. In Formula (I), R 1 , R 2 , R 3 , R 4 , R 3′ , R 10 and R 11 are as described herein. The invention also encompasses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of treating cognitive disorders using compounds of Formula (I).

  本发明涉及用于治疗或预防认知障碍（例如阿尔茨海默病）的N-取代苯磺酰胺。在式（I）中，R1、R2、R3、R4、R3′、R10和R11如所述。本发明还包括包含式（I）化合物的药物组合物，以及使用式（I）化合物治疗认知障碍的方法。
• N-Substituted Benzene Sulfonamides
  申请人：Neitzel Martin

  公开号：US20070191341A1

  公开（公告）日：2007-08-16

  Disclosed are N-substituted benzenesulfonamides for use in treating or preventing cognitive disorders, such as Alzheimer's Disease. In Formula (I), R 1 , R 2 , R 3 , R 4 , R 3′ , R 10 and R 11 are as described herein. The invention also encompasses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of treating cognitive disorders using compounds of Formula (I).

  本发明涉及N-取代苯磺酰胺，用于治疗或预防认知障碍，例如阿尔茨海默病。在式（I）中，R1、R2、R3、R4、R3′、R10和R11如本文所述。本发明还涵盖了包含式（I）化合物的制药组合物，以及使用式（I）化合物治疗认知障碍的方法。
• CHEMICAL COMPOUNDS HAVING ANTIVIRAL ACTIVITY AGAINST DENGUE VIRUS AND OTHER FLAVIVIRUSES
  申请人：Centro De Ingenieria Genetica Y Biotecnologia

  公开号：EP2258356B1

  公开（公告）日：2017-09-27
• AGONISTS THAT ENHANCE BINDING OF INTEGRIN-EXPRESSING CELLS TO INTEGRIN RECEPTORS
  申请人：Texas Heart Institute

  公开号：EP2640721A2

  公开（公告）日：2013-09-25
• COMPOSITIONS AND METHODS TO IMPROVE THE HOMING AND GRAFTING OF HEMATOPOETIC STEM CELLS
  申请人：7 HILLS INTERESTS, LLC

  公开号：EP3104867A1

  公开（公告）日：2016-12-21