2H-2-acetyl-4,6-dimethylpyrido<3,2-d>isothiazolin-3-one | 97248-88-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2H-2-acetyl-4,6-dimethylpyrido<3,2-d>isothiazolin-3-one
• 英文别名: Isothiazolo(5,4-b)pyridin-3(2H)-one, 2-acetyl-4,6-dimethyl-；2-acetyl-4,6-dimethyl-[1,2]thiazolo[5,4-b]pyridin-3-one
• CAS: 97248-88-9
• 化学式: C₁₀H₁₀N₂O₂S
• 分子量: 222.268
• InChiKey: KGXOUAFSIHRDIX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  75.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4,6-二甲基异噻唑并[5,4-b]吡啶-3(2H)-酮 生成 2H-2-acetyl-4,6-dimethylpyrido<3,2-d>isothiazolin-3-one
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• Zawisza; Malinka, Farmaco, Edizione Scientifica, 1985, vol. 40, # 2, p. 124 - 132
  作者：Zawisza、Malinka

  DOI：——

  日期：——
• ZAWISZA, T.;MALINKA, W., FARMACO. ED. SCI., 1985, 40, N 2, 124-132
  作者：ZAWISZA, T.、MALINKA, W.

  DOI：——

  日期：——
• ——
  作者：ZAWISZA T.、 MALINKA W.

  DOI：——

  日期：——
• Methods and Compositions for Modulating Glycosylation
  申请人：Walker Kahne Suzanne

  公开号：US20090325944A1

  公开（公告）日：2009-12-31

  The invention relates to methods and products for modulating glycosylation of proteins. The invention is useful for treating glycosylation-associated disorders such as neurodegeneration, diabetes, including complications of diabetes such as insulin resistance, nephropathy, microvascular damage, and endothelial dysfunction. The invention also relates in part to assays that are useful for identifying and testing candidate compounds for modulating glycosylation of proteins.
• [EN] METHODS AND COMPOSITIONS FOR MODULATING GLYCOSYLATION<br/>[FR] PROCEDES ET COMPOSITIONS PERMETTANT DE MODULER LA GLYCOSYLATION
  申请人：HARVARD COLLEGE

  公开号：WO2007120638A2

  公开（公告）日：2007-10-25

  [EN] The invention relates to methods and products for modulating glycosylation of proteins. The invention is useful for treating glycosylation-associated disorders such as neurodegeneration, diabetes, including complications of diabetes such as insulin resistance, nephropathy, microvascular damage, and endothelial dysfunction. The invention also relates in part to assays that are useful for identifying and testing candidate compounds for modulating glycosylation of proteins.
  [FR] L'invention porte sur des procédés et des produits permettant de moduler la glycosylation des protéines. L'invention est utile pour traiter des troubles associés à la glycosylation tels que la neurodégénérescence, le diabète et ses complications dont la résistance à l'insuline, la néphropathie, les dommages microvasculaires et le dysfonctionnement endothélial. L'invention porte également en partie sur des dosages qui sont utiles pour identifier et tester des composés candidats pour moduler la glycosylation de protéines.