2,4-Difluoro-1-(2-methylbutan-2-yl)benzene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,4-Difluoro-1-(2-methylbutan-2-yl)benzene
• 英文别名: 2,4-difluoro-1-(2-methylbutan-2-yl)benzene
• 化学式: C₁₁H₁₄F₂
• 分子量: 184.23
• InChiKey: ZHQIJMFMGQVQBW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Inhibitors of indoleamine-2,3-dioxygenase for the treatment of cancer
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US10399932B2

  公开（公告）日：2019-09-03

  There are disclosed compounds of formula (I) that modulate or inhibit the enzymatic activity of indoleamine-2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.

  本发明公开了调节或抑制吲哚胺-2,3-二氧化酶（IDO）酶活性的式(I)化合物、含有所述化合物的药物组合物以及利用本发明化合物治疗增殖性疾病（如癌症、病毒感染和/或炎症性疾病）的方法。
• IDO inhibitors
  申请人：Bristol-Myers Squibb Company

  公开号：US10689331B2

  公开（公告）日：2020-06-23

  There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.

  本发明公开了调节或抑制吲哚胺-2,3-二氧化酶（IDO）酶活性的化合物、含有上述化合物的药物组合物以及利用本发明化合物治疗增殖性疾病（如癌症、病毒感染和/或炎症性疾病）的方法。
• Potent antiviral pyrazolopyridine compounds
  申请人：The Regents of the University of California

  公开号：US11059817B2

  公开（公告）日：2021-07-13

  The present technology provides compounds according to Formulas (I), (II), or (III) useful in inhibiting an enterovirus, paramyxovirus, respiratory virus, flaviviridae virus, bunyaviridae virus, togaviridae virus, or rabies virus in a cell and/or treating subjects suffering from an enterovirus, paramyxovirus, respiratory virus, flaviviridae virus, bunyaviridae virus, togaviridae virus, or rabies virus.

  本技术提供了根据式(I)、(II)或(III)的化合物，这些化合物可用于抑制细胞中的肠道病毒、副粘病毒、呼吸道病毒、黄病毒科病毒、布尼亚病毒科病毒、托加病毒科病毒或狂犬病毒，和/或治疗患有肠道病毒、副粘病毒、呼吸道病毒、黄病毒科病毒、布尼亚病毒科病毒、托加病毒科病毒或狂犬病毒的患者。
• COSMETIC AND PHARMACEUTICAL COMPOSITIONS AND METHODS USING 2-DECARBOXY-2-PHOSPHINICO DERIVATIVES
  申请人：Duke University

  公开号：US20170239160A1

  公开（公告）日：2017-08-24

  A method for treating hair loss in mammals uses compositions containing 2-decarboxy-2-phosphinico prostaglandin derivatives. The compositions can be applied topically to the skin. The compositions can arrest hair loss, reverse hair loss, and promote hair growth. Compositions containing 2-decarboxy-2-phosphinico prostaglandin derivatives can also be used to lower intraocular pressure and treat bone disorders.
• INHIBITORS OF INDOLEAMINE-2,3-DIOXYGENASE FOR THE TREATMENT OF CANCER
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20180079712A1

  公开（公告）日：2018-03-22

  There are disclosed compounds of formula (I) that modulate or inhibit the enzymatic activity of indoleamine-2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.