Ethyl 3-(2-chloroanilino)-2-cyanoacrylate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Ethyl 3-(2-chloroanilino)-2-cyanoacrylate
• 英文别名: ethyl (E)-3-(2-chloroanilino)-2-cyanoprop-2-enoate
• 化学式: C₁₂H₁₁ClN₂O₂
• 分子量: 250.68
• InChiKey: SWCQAAUPCCUXBT-CMDGGOBGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  62.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  邻氯苯胺 、 原甲酸三乙酯 、 氰乙酸乙酯 、 氯化锌 以92%的产率得到
  参考文献：
  名称：

  AYYANGAR, N. R.;LAHOTI, R. J.;DANIEL, T., ORG. PREP. AND PROCED. INT., 1982, 14, N 5, 327-331

  摘要：

  DOI：

文献信息

• TREATING CANCER
  申请人：Agency for Science, Technology and Research

  公开号：EP2908843B1

  公开（公告）日：2019-09-04
• COMPOSITIONS AND METHODS FOR INHIBITING EZH2
  申请人：Chinnaiyan Arul M.

  公开号：US20110251216A1

  公开（公告）日：2011-10-13

  The present invention relates to therapeutic targets for cancer. In particular, the present invention relates to small molecules and nucleic acids that target EZH2 expression in cancer (e.g., prostate cancer, breast cancer, other solid tumors, multiple myeloma).
• METHOD OF TREATING CANCER
  申请人：Agency for Science, Technology and Research

  公开号：US20150258175A1

  公开（公告）日：2015-09-17

  The present invention relates to a pharmaceutical composition comprising a histone-lysine N-methyltransferase EZH2 (enhancer of zeste homolog 2) inhibitor and an enhancer of interferon-gamma receptor activity. The invention also relates to method of treating a patient having cancer, comprising administration of the pharmaceutical composition.
• [EN] COMPOSITIONS AND METHODS FOR INHIBITING EZH2<br/>[FR] COMPOSITIONS ET MÉTHODES D'INHIBITION D'EZH2
  申请人：UNIV MICHIGAN

  公开号：WO2011103016A2

  公开（公告）日：2011-08-25

  The present invention relates to therapeutic targets for cancer. In particular, the present invention relates to small molecules and nucleic acids that target EZH2 expression in cancer (e.g., prostate cancer, breast cancer, other solid tumors, multiple myeloma).
• AYYANGAR, N. R.;LAHOTI, R. J.;DANIEL, T., ORG. PREP. AND PROCED. INT., 1982, 14, N 5, 327-331
  作者：AYYANGAR, N. R.、LAHOTI, R. J.、DANIEL, T.

  DOI：——

  日期：——