1-Tert-butylpyridin-1-ium

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-Tert-butylpyridin-1-ium
• 化学式: C9H14N+
• 分子量: 136.21
• InChiKey: TZWNFYNYOUMRRE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  3.9
• 氢给体数：
  0
• 氢受体数：
  0

文献信息

• COMPOUNDS AND METHODS TO TREAT ORGANOPHOSPHORUS POISONING
  申请人：University of Iowa Research Foundation

  公开号：US20140323473A1

  公开（公告）日：2014-10-30

  Organophosphate (OP) nerve agents and pesticides are potent inhibitors of acetylcholinesterase (AChE). Though oxime nucleophiles can reactivate an AChE-phosphyl adduct, the adduct can undergo a reaction called aging, leading to an aged-AChE adduct. The invention provides compounds and methods that can be used to reactivate an aged-AChE adduct. Such compounds and methods are useful to counteract organophosphorus poisoning.

  有机磷酸酯（OP）神经毒剂和杀虫剂是乙酰胆碱酯酶（AChE）的强效抑制剂。虽然氧化物亲核试剂可以重新激活AChE-磷酰加合物，但该加合物可能会发生一种称为老化的反应，导致形成老化的AChE加合物。该发明提供了可以用于重新激活老化的AChE加合物的化合物和方法。这些化合物和方法对抗有机磷中毒非常有用。
• CATALYSTS AND METHODS FOR POLYMER SYNTHESIS
  申请人：NOVOMER, INC.

  公开号：US20130144032A1

  公开（公告）日：2013-06-06

  The present invention provides unimolecular metal complexes having increased activity in the copolymerization of carbon dioxide and epoxides. Also provided are methods of using such metal complexes in the synthesis of polymers. According to one aspect, the present invention provides metal complexes comprising an activating species with co-catalytic activity tethered to a multidentate ligand that is coordinated to the active metal center of the complex.

  本发明提供了在二氧化碳和环氧化物的共聚合中具有增强活性的单分子金属配合物。还提供了使用这种金属配合物在合成聚合物中的方法。根据一个方面，本发明提供了包括与具有共催化活性的活化物种相耦合的多齿配体的金属配合物，该多齿配体与复合物的活性金属中心配位。
• Treatment of proliferative disorders with amino-substituted (E)-2,6- dialkoxystyryl 4-substituted benzylsulfones
  申请人：Reddy E. Premkumar

  公开号：US20090281066A1

  公开（公告）日：2009-11-12

  Methods of treating cancer using compounds according to Formula (I) are disclosed herein, wherein X, X 1 , X 2 , R a , R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , g, M, y, a, b, d, e, V, W, Z and Q are as defined herein.

  本文披露了使用公式（I）中的化合物治疗癌症的方法，其中X，X1，X2，Ra，R1，R2，R3，R4，R5，R6，R7，g，M，y，a，b，d，e，V，W，Z和Q的定义如下。
• FLUOROPHORE AND FLUORESCENT SENSOR COMPOUND CONTAINING SAME
  申请人：Higgs Timothy Charles

  公开号：US20120156793A1

  公开（公告）日：2012-06-21

  The invention provides fluorophores of formulae (I) and (II) and also fluorescent sensor compounds comprising fluorophore moieties based on such fluorophores in combination with a receptor moiety. There is further provided a method of sensing the presence of a target analyte using the fluorescent sensor compound, as well as the use of the fluorescent sensor compounds to sense a target analyte.

  本发明提供了式(I)和(II)的荧光团，以及包含基于这些荧光团的荧光传感器化合物和受体基团的组合的荧光传感器化合物。还提供了一种使用荧光传感器化合物感知目标分析物的方法，以及使用荧光传感器化合物感知目标分析物的用途。
• ANALYSIS OF ESTRADIOL AND ANALYTES WITH PHENOLIC OH USING LABELING CHEMISTRY AND LC-MSMS WORKFLOW
  申请人：DH Technologies Development Pte. Ltd.

  公开号：US20150051111A1

  公开（公告）日：2015-02-19

  A method is described for mass spectrometric analysis of a sample comprising phenolic OH, such as a steroid comprising a phenolic OH, using a quaternary amino oxy Cookson (QAOC) reagent. The QAOC reagent can improve ionization and fragmentation properties of phenolic OH samples, which can thereby improve quantitation and identification. The method can include derivatizing the phenolic OH sample with the QAOC reagent to create an adduct and analyzing the adduct using mass spectrometry. Derivatization of the sample can be a one-step reaction where the QAOC reagent comprises an aminooxy MS tag or can be a multi-step reaction, where the adduct is formed by the reaction of carbonyl substituted PTAD based reagent and the sample followed by combination with an aminooxy MS tag. The sample can also be enriched prior to reacting it with the reagent. The method can also allow for multiplexing.

  本文介绍了一种用四元氨氧基库克森（QAOC）试剂对含酚羟基的样品进行质谱分析的方法，例如含有酚羟基的类固醇。 QAOC试剂可以改善酚羟基样品的电离和碎片化特性，从而提高定量和鉴定能力。该方法可以包括使用QAOC试剂对酚羟基样品进行衍生化以创建一个加合物，并使用质谱分析对加合物进行分析。样品的衍生化可以是一步反应，其中QAOC试剂包含氨氧基MS标记，也可以是多步反应，其中加合物是由含有碳酰基取代的PTAD试剂与样品反应后与氨氧基MS标记结合形成的。在对样品进行反应之前，还可以对其进行富集。该方法还可以允许多重复分析。