2,3-Dihydropyridine-4-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2,3-Dihydropyridine-4-carboxamide
• 英文别名: 2,3-dihydropyridine-4-carboxamide
• 化学式: C₆H₈N₂O
• 分子量: 124.14
• InChiKey: FRJBXVUNPZLVTQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] AZACARBAZOLE BTK INHIBITORS<br/>[FR] INHIBITEURS AZACARBAZOLE DE LA BTK
  申请人：MERCK SHARP & DOHME

  公开号：WO2016161570A1

  公开（公告）日：2016-10-13

  The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, wherein CH, R1, R1a, R1b, R2, R3, and the subscripts m1, m2, p, q, and t are as set forth herein. The present invention also provides pharmaceutical compositions comprising these compounds and their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula (I) in the treatment of Btk mediated disorders.