2-(4-Fluorophenyl)acetimidamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-Fluorophenyl)acetimidamide
• 英文别名: 2-(4-fluorophenyl)ethanimidamide
• 化学式: C₈H₉FN₂
• mdl: MFCD05663124
• 分子量: 152.17
• InChiKey: LBMVNBZGHAZJNN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.125
• 拓扑面积：
  49.9
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Dipeptidyl Peptidase-IV Inhibiting Compounds, Method Of Preparing The Same, And Pharmaceutical Compositions Containing The Same As An Active Agent
  申请人：Lee Chang-Seok

  公开号：US20080188471A1

  公开（公告）日：2008-08-07

  The present invention relates to novel compounds exhibiting good inhibitory activity versus Dipeptidyl Peptidase-IV (DPP-IV), methods of preparing the same and pharmaceutical compositions containing the same as an active agent.

  本发明涉及一种新型化合物，表现出良好的抑制二肽基肽酶-IV（DPP-IV）活性，制备该化合物的方法以及含有该化合物作为活性剂的制药组合物。
• Pyrimido [4,5-D] Azepine Derivatives As 5-HT2C Agonists
  申请人：Andrews Mark

  公开号：US20100113422A1

  公开（公告）日：2010-05-06

  The present invention provides a compound of formula (I): or a pharmaceutically acceptable salt thereof wherein the variables R 1 , R 2 , R 3a , R 3b , R 3b , R 3d , and R 100 are as defined herein. The invention is also directed to pharmaceutical compositions comprising the compounds of formula (I) and methods of treating a 5-HT 2c receptor-mediated disorders with a compound of formula (I) or a pharmaceutical composition comprising a compound of formula (I).

  本发明提供了式（I）的化合物：或其药学上可接受的盐，其中变量R1、R2、R3a、R3b、R3b、R3d和R100如本文所定义。本发明还涉及包括式（I）化合物的制药组合物，以及使用式（I）的化合物或包括式（I）的制药组合物治疗5-HT2c受体介导的疾病的方法。
• POLY(ADP-RIBOSE) POLYMERASE INHIBITORS CONSISTING OF PYRIMIDINE DERIVATIVES
  申请人：Meiji Seika Kaisha, Ltd.

  公开号：EP1142881A1

  公开（公告）日：2001-10-10

  A medicament for therapeutic and/or preventive treatment of a brain disease, which comprises a compound represented by the following general formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient: wherein R represents hydrogen atom, a C1-C8 alkyl group, a substituted C1-C8 alkyl group, an aryl group, a substituted aryl group, an aryl(C1-C8)alkyl group and the like; Y represents hydrogen atom or -C(R2)R3 (R2 and R3 represent hydrogen atom, a C1-C8 alkyl group, a C1-C8 alkoxy(C1-C8)alkyl group, a hydroxy(C1-C8)alkyl group and the like); symbol "a" represents single bond when Y represents hydrogen atom, or "a" represents double bound when Y represents -C(R2)R3; -A-B- represents -CH2-CH2-, -S-CH2-, -O-CH2-, -CH2-S-, -CH2-O-, -SO-CH2-, -CH2-SO-, -SO2-CH2-, or -CH2-SO2-; and Z represents -CH2- or single bond.

  一种用于治疗和/或预防脑部疾病的药物，其活性成分包括下式通式(I)所代表的化合物或其药学上可接受的盐： 其中 R 代表氢原子、C1-C8 烷基、取代的 C1-C8 烷基、芳基、取代的芳基、芳基（C1-C8）烷基等；Y 代表氢原子或 -C(R2)R3 （R2 和 R3 代表氢原子、C1-C8 烷基、C1-C8 烷氧基（C1-C8）烷基、羟基（C1-C8）烷基等）；符号 "a "在 Y 代表氢原子时代表单键，或 "a "在 Y 代表-C(R2)R3 时代表双键；-A-B-代表-CH2- -、-S- -、-O- -、- -S-、- -O-、-SO- -、- -SO-、-SO2-或- -SO2-；Z 代表- -或单键。
• DIPEPTIDYL PEPTIDASE-IV INHIBITING COMPOUNDS, METHODS OF PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS AN ACTIVE AGENT
  申请人：LG Life Sciences Ltd.

  公开号：EP1863812B1

  公开（公告）日：2010-07-14
• EP1863812A4
  申请人：——

  公开号：EP1863812A4

  公开（公告）日：2009-06-24