1-t-Butylpiperidin-4-spiro-5'-hydantoin | 33554-19-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 1-t-Butylpiperidin-4-spiro-5'-hydantoin
• 英文别名: 8-tert-butyl-1,3,8-triaza-spiro[4.5]decane-2,4-dione；8-tert-butyl-2-oxo-1,3-diaza-8-azoniaspiro[4.5]dec-3-en-4-olate
• CAS: 33554-19-7
• 化学式: C₁₁H₁₉N₃O₂
• 分子量: 225.291
• InChiKey: HGJUBXJRBQNQAF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  61.4
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• TRICYCLIC GYRASE INHIBITORS
  申请人：Bensen Daniel

  公开号：US20120238751A1

  公开（公告）日：2012-09-20

  Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.

  本文披露了具有式I结构的化合物，以及作为抗菌有效的三环酶抑制剂的药用盐、酯和前药，相关的药物组合物、用途和制备该化合物的方法也在考虑之中。
• Indazole-carboxamide compounds
  申请人：Fatheree Paul

  公开号：US20060135764A1

  公开（公告）日：2006-06-22

  The invention provides novel indazole-carboxamide 5-HT 4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT 4 receptor activity, and processes and intermediates useful for preparing such compounds.

  这项发明提供了新型的吲唑-羧酰胺5-HT4受体激动剂化合物。该发明还提供了包括这些化合物的药物组合物，使用这些化合物治疗与5-HT4受体活性相关疾病的方法，以及用于制备这些化合物的过程和中间体。
• Cgrp Receptor Antagonists
  申请人：Burgey S. Christopher

  公开号：US20080070899A1

  公开（公告）日：2008-03-20

  The present invention is directed to compounds of Formula I: Formula I: I and Formula II: (where variables R 1 , R 2 , R 3 , R 4 , A, B, J, Q, T, V, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

  本发明涉及公式I和公式II的化合物： 公式I：I 和公式II：（其中变量R1、R2、R3、R4、A、B、J、Q、T、V、W、X和Y的定义如本文所述），其作为CGRP受体拮抗剂在治疗或预防涉及CGRP的疾病方面具有用途，例如头痛、偏头痛和群集头痛。本发明还涉及包含这些化合物的制药组合物以及使用这些化合物和组合物在预防或治疗涉及CGRP的疾病方面的用途。
• CGRP RECEPTOR ANTAGONISTS
  申请人：Burgey Christopher S.

  公开号：US20100113419A1

  公开（公告）日：2010-05-06

  The present invention is directed to compounds of Formula I: Formula I: Formula II: (where variables R 1 , R 2 , R 3 , R 4 , A, B, J, Q, T, V, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

  本发明涉及I式化合物：I式：II式：（其中变量R1、R2、R3、R4、A、B、J、Q、T、V、W、X和Y的定义如本文所述），用作CGRP受体拮抗剂，有助于治疗或预防CGRP参与的疾病，如头痛、偏头痛和集群头痛。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗CGRP参与的疾病方面的使用。
• INDAZOLE-CARBOXAMIDE COMPOUNDS
  申请人：FATHEREE Paul

  公开号：US20100292223A1

  公开（公告）日：2010-11-18

  The invention provides novel indazole-carboxamide 5-HT 4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT 4 receptor activity, and processes and intermediates useful for preparing such compounds.

  该发明提供了新型的吲唑-羧酰胺5-HT4受体激动剂化合物。该发明还提供了包含这种化合物的药物组合物，使用这种化合物治疗与5-HT4受体活性相关的疾病的方法，以及用于制备这种化合物的过程和中间体。