[(2S,3R,4R,5R,6R)-5-azido-2,5-dihydroxy-6-methyl-4-phenylmethoxyoxan-3-yl] 4-oxopentanoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [(2S,3R,4R,5R,6R)-5-azido-2,5-dihydroxy-6-methyl-4-phenylmethoxyoxan-3-yl] 4-oxopentanoate
• 化学式: C18H23N3O7
• 分子量: 393.4
• InChiKey: NDMDEWYKNSDEKV-IDXRPEPOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  28
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  117
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• Antibodies for the Detection of Bacillus Anthracis and Vaccine Against B. Anthracis Infections
  申请人：Werz Daniel B.

  公开号：US20090155299A1

  公开（公告）日：2009-06-18

  The present invention relates to conjugates of oligosaccharides of formula 1, wherein R is a linker to a carrier protein and optionally comprises up to three further saccharides, 5 and which are useful for vaccination, methods of synthesis of such conjugates, antibodies against this antigen, hybridoma producing monoclonal antibodies against this antigen, assays using these antibodies for the detection of B. anthracis spores and kits comprising these antibodies, and a vaccine for the prevention of B. anthracis infection comprising the conjugates of oligosaccharides of formula 1. Monoclonal antibodies 10 according to the invention selectively bind to B. anthracis , but not to related bacteria such as B. subtilis, B. cereus and other bacteria of this group such as B. thuringiensis .

  本发明涉及公式1的寡糖结合物，其中R是连接到载体蛋白质的连接物，可选地包含多达三个进一步的糖类，其用于疫苗接种，合成这种结合物的方法，针对这种抗原的抗体，产生针对这种抗原的单克隆抗体的杂交瘤，使用这些抗体进行B. anthracis孢子检测的测定和包含这些抗体的试剂盒，以及包含公式1的寡糖结合物的B. anthracis感染预防疫苗。根据本发明的单克隆抗体能够选择性地结合到B. anthracis，但不结合到相关细菌，例如B. subtilis、B. cereus和该组细菌的其他细菌，例如B. thuringiensis。
• ANTIBODIES FOR THE DETECTION OF BACILLUS ANTHRACIS AND VACCINE AGAINST B. ANTHRACIS INFECTIONS
  申请人：ETH Zürich

  公开号：EP2012821A2

  公开（公告）日：2009-01-14
• US7901687B2
  申请人：——

  公开号：US7901687B2

  公开（公告）日：2011-03-08
• [EN] ANTIBODIES FOR THE DETECTION OF BACILLUS ANTHRACIS AND VACCINE AGAINST B. ANTHRACIS INFECTIONS<br/>[FR] ANTICORPS POUR LA DÉTECTION DE BACILLUS ANTHRACIS ET VACCIN CONTRE DES INFECTIONS À B. ANTHRACIS
  申请人：ETH ZUERICH

  公开号：WO2007125089A2

  公开（公告）日：2007-11-08

  [EN] 35 Abstract The present invention relates to conjugates of oligosaccharides of formula 1, wherein R is a linker to a carrier protein and optionally comprises up to three further saccharides, 5 and which are useful for vaccination, methods of synthesis of such conjugates, antibodies against this antigen, hybridoma producing monoclonal antibodies against this antigen, assays using these antibodies for the detection of B. anthracis spores and kits comprising these antibodies, and a vaccine for the prevention of B. anthracis infection comprising the conjugates of oligosaccharides of formula 1. Monoclonal antibodies 10 according to the invention selectively bind to B. anthracis, but not to related bacteria such as B. subtilis, B. cereus and other bacteria of this group such as B. thuringiensis.
  [FR] La présente invention concerne des conjugués d'oligosaccharides de formule 1, dans laquelle R est un segment de liaison à une protéine porteuse et comprend éventuellement jusqu'à trois autres saccharides, qui sont utiles pour la vaccination, des procédés de synthèse de ces conjugués, des anticorps dirigés contre cet antigène, un hybridome produisant des anticorps monoclonaux dirigés contre cet antigène, des dosages utilisant ces anticorps pour la détection de spores de B. anthracis et des kits comprenant ces anticorps, ainsi qu'un vaccin pour la prévention d'une infection à B. anthracis comprenant les conjugués d'oligosaccharides de formule 1. Les anticorps monoclonaux de l'invention se lient sélectivement à B. anthracis mais pas à des bactéries apparentées telles que B. subtilis, B. cereus et d'autres bactéries de ce groupe telles que B. thuringiensis. ORTH3C O O HO H3C O O NH OH HO HO O Me 1