1-(2-Methoxyphenyl)-3-methylnaphthalene | 1072849-23-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-(2-Methoxyphenyl)-3-methylnaphthalene
• 英文别名: 1-(2-methoxyphenyl)-3-methylnaphthalene
• CAS: 1072849-23-0
• 化学式: C₁₈H₁₆O
• 分子量: 248.324
• InChiKey: YJMBMEDDEDTSAG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  在 europium(III) trifluoromethanesulfonate 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 16.0h， 生成 2-methyl-1-(2-methoxyphenyl)naphthalene 、 1-(2-Methoxyphenyl)-3-methylnaphthalene
  参考文献：
  名称：

  Synthesis of Substituted Naphthalenes via a Catalytic Ring-Expansion Rearrangement

  摘要：

  A new methodology for the preparation of substituted naphthalenes starting from readily available indenones, organometal reagents, and trimethylsilyldiazomethane via a catalytic rearrangement process is described. Hindered biaryl naphthalenes, including triortho-substituted biaryls, can be accessed through our method. Our results are consistent with a mechanism involving a benzobenzvalene intermediate.

  DOI：

  10.1021/ol8019617

文献信息

• Synthesis of Substituted Naphthalenes via a Catalytic Ring-Expansion Rearrangement
  作者：Adam C. Glass、Benjamin B. Morris、Lev N. Zakharov、Shih-Yuan Liu

  DOI：10.1021/ol8019617

  日期：2008.11.6

  A new methodology for the preparation of substituted naphthalenes starting from readily available indenones, organometal reagents, and trimethylsilyldiazomethane via a catalytic rearrangement process is described. Hindered biaryl naphthalenes, including triortho-substituted biaryls, can be accessed through our method. Our results are consistent with a mechanism involving a benzobenzvalene intermediate.