N-[4-(carboxymethoxy)phenyl]iminodiacetic acid | 1252652-63-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[4-(carboxymethoxy)phenyl]iminodiacetic acid
• 英文别名: H3cpia；2-[4-(carboxymethoxy)-N-(carboxymethyl)anilino]acetic acid
• CAS: 1252652-63-3
• 化学式: C₁₂H₁₃NO₇
• 分子量: 283.238
• InChiKey: NYTXLXJBIJILNX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  20
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  124
• 氢给体数：
  3
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  nickel(II) nitrate hexahydrate 、 N-[4-(carboxymethoxy)phenyl]iminodiacetic acid 在 NaOH 作用下， 以 水 为溶剂， 以25.5%的产率得到[(nickel(II))3(N-[4-(carboxymethoxy)phenyl]iminodiacetate)2(H2O)12] hexahydrate
  参考文献：
  名称：

  四种新型过渡金属配合物与 3-[4-(羧甲氧基)苯基]丙酸和 N-[4-(羧甲氧基)苯基]亚氨基二乙酸的超分子结构

  摘要：

  四种新的过渡金属配合物：[Cu(Hcppa)2(H2O)2](1)、[Co2(cppa)2(H2O)10](2)、[Co3(cpia)2(H2O)8]·2H2O( 3) 和 [Ni3(cpia)2(H2O)12]·6H2O (4) {H2cppa = 3-(4-(羧基甲氧基)苯基]丙酸；H3cpia = N-[4-(羧基甲氧基)苯基]亚氨基二乙酸}合成和表征。配合物1和2显示单核结构，配合物3和4显示双核结构。所有配合物通过氢键延伸到3D超分子网络，其中配合物3和4显示微孔结构。在配合物2-4中，水簇被配位相互作用和氢键的协同结合所困，形成不同的一维金属-水链结构。讨论了配合物1-4的热稳定性。

  DOI：

  10.1002/zaac.201000228
• 作为产物：
  描述：

  对氨基苯酚 、 氯乙酸 在 potassium hydroxide 作用下， 以 水 为溶剂， 反应 10.0h， 以74%的产率得到N-[4-(carboxymethoxy)phenyl]iminodiacetic acid
  参考文献：
  名称：

  Two Series of Luminescent Flexible Polycarboxylate Lanthanide Coordination Complexes with Double Layer and Rectangle Metallomacrocycle Structures

  摘要：

  Two series of eight polycarboxylate lanthanide coordination complexes, namely, [Ln(cpia)(H2O)(2)]center dot 4H(2)O {Ln = Ce (1), Nd (2), and Sm (3)} and [Ln(cpia)(H2O)(n)](2)center dot 2H(2)O {Ln = Eu (4), Gd (5), Tb (6), Er (7), and Lu (8), n = 5 in 4-7; n = 4 in 8} {H(3)cpia = N-[4-(carboxymethoxy)phenyl]iminodiacetic acid}, have been synthesized by self-assembly and characterized by IR, thermogravimetric analysis, and X-ray crystallography. Complexes 1-3 are isomorphic featuring two-dimensional double layer structures, while the isomorphic complexes 4-8 exhibit [2 + 2] rectangle metallomacrocycle structures. Further, photoluminescence (PL) spectra of complexes 2, 4, and 6 show the strong characteristic luminescence of Eu(III), Tb(III), and Nd(III) ions, respectively, suggesting that cpia(3-) is able to efficiently sensitize the luminescence of lanthanide ions.

  DOI：

  10.1021/cg400174r

文献信息

• Supramolecular Architectures of Four New Transition Metal Complexes with 3-[4-(Carboxymethoxy)phenyl]propanoic Acid and N-[4-(Carboxymethoxy)phenyl]iminodiacetic Acid
  作者：Chong-Bo Liu、Hui-Liang Wen、Yun-Nan Gong、Xiao-Ming Liu、Sheng-Shui Tan

  DOI：10.1002/zaac.201000228

  日期：2011.1

  transition metal complexes: [Cu(Hcppa)2(H2O)2] (1), [Co2(cppa)2(H2O)10] (2), [Co3(cpia)2(H2O)8]·2H2O (3) and [Ni3(cpia)2(H2O)12]·6H2O (4) H2cppa = 3-(4-(carboxymethoxy)phenyl]propanoic acid; H3cpia = N-[4-(carboxymethoxy)phenyl]iminodiacetic acid} were synthesized and characterized. Complexes 1 and 2 show mononuclear structures, complexes 3 and 4 exhibit dinuclear structures. All complexes extend to

  四种新的过渡金属配合物：[Cu(Hcppa)2(H2O)2](1)、[Co2(cppa)2(H2O)10](2)、[Co3(cpia)2(H2O)8]·2H2O( 3) 和 [Ni3(cpia)2(H2O)12]·6H2O (4) H2cppa = 3-(4-(羧基甲氧基)苯基]丙酸；H3cpia = N-[4-(羧基甲氧基)苯基]亚氨基二乙酸}合成和表征。配合物1和2显示单核结构，配合物3和4显示双核结构。所有配合物通过氢键延伸到3D超分子网络，其中配合物3和4显示微孔结构。在配合物2-4中，水簇被配位相互作用和氢键的协同结合所困，形成不同的一维金属-水链结构。讨论了配合物1-4的热稳定性。
• Two Series of Luminescent Flexible Polycarboxylate Lanthanide Coordination Complexes with Double Layer and Rectangle Metallomacrocycle Structures
  作者：Guang-Feng Hou、Hong-Xing Li、Wei-Zuo Li、Peng-Fei Yan、Xiao-Hong Su、Guang-Ming Li

  DOI：10.1021/cg400174r

  日期：2013.8.7

  Two series of eight polycarboxylate lanthanide coordination complexes, namely, [Ln(cpia)(H2O)(2)]center dot 4H(2)O Ln = Ce (1), Nd (2), and Sm (3)} and [Ln(cpia)(H2O)(n)](2)center dot 2H(2)O Ln = Eu (4), Gd (5), Tb (6), Er (7), and Lu (8), n = 5 in 4-7; n = 4 in 8} H(3)cpia = N-[4-(carboxymethoxy)phenyl]iminodiacetic acid}, have been synthesized by self-assembly and characterized by IR, thermogravimetric analysis, and X-ray crystallography. Complexes 1-3 are isomorphic featuring two-dimensional double layer structures, while the isomorphic complexes 4-8 exhibit [2 + 2] rectangle metallomacrocycle structures. Further, photoluminescence (PL) spectra of complexes 2, 4, and 6 show the strong characteristic luminescence of Eu(III), Tb(III), and Nd(III) ions, respectively, suggesting that cpia(3-) is able to efficiently sensitize the luminescence of lanthanide ions.