6-羟基苯并[b]噻吩-2-磺酰胺乙酸酯 | 96803-92-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 中文名称: 6-羟基苯并[b]噻吩-2-磺酰胺乙酸酯
• 英文名称: 6-acetoxybenzothiophene-2-sulfonamide
• 英文别名: 6-Hydroxybenzo(b)thiophene-2-sulfonamide acetate ester；(2-sulfamoyl-1-benzothiophen-6-yl) acetate
• CAS: 96803-92-8
• 化学式: C₁₀H₉NO₄S₂
• 分子量: 271.318
• InChiKey: XOFVNNKNKJTRRS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  123
• 氢给体数：
  1
• 氢受体数：
  6

安全信息

• 海关编码：
  2935009090

反应信息

• 作为产物：
  描述：

  3-甲氧基苯硫酚 在 吡啶 、 吡啶盐酸盐 、 potassium carbonate 作用下， 以 乙酸乙酯 、 丙酮 为溶剂， 反应 21.5h， 生成 6-羟基苯并[b]噻吩-2-磺酰胺乙酸酯
  参考文献：
  名称：

  Topically active carbonic anhydrase inhibitors. 2. Benzo[b]thiophenesulfonamide derivatives with ocular hypotensive activity

  摘要：

  Derivatives of benzo[b]thiophene-2-sulfonamide were prepared to investigate their potential utility as topically active inhibitors of ocular carbonic anhydrase. Such an agent would be useful in the treatment of glaucoma. Among the compounds described are 6-hydroxybenzo[b]thiophene-2-sulfonamide (16) and its acetate ester (23), which are among the most potent ocular hypotensive agents in this class, as assessed in the alpha-chymotrypsinized rabbit. These compounds were selected for clinical evaluation.

  DOI：

  10.1021/jm00132a009

文献信息

• 2-Sulfamoylbenzo (b) thiophene derivatives, their preparation and pharmaceutical composition for the treatment of elevated intraocular pressure
  申请人：Merck & Co., Inc.

  公开号：EP0129478A2

  公开（公告）日：1984-12-27

  Novel 2-suifamoylbenzo [b]thiophenes and derivatives thereof are shown to be useful for the treatment of elevated intraocular pressure in compositions including ophthalmic drops and inserts.

  新型 2-suifamoylbenzo[b]噻吩及其衍生物可用于治疗眼压升高，其成分包括滴眼液和眼药水。
• SHEPARD, K. L.;GRAHAM, S. L.
  作者：SHEPARD, K. L.、GRAHAM, S. L.

  DOI：——

  日期：——
• GRAHAM, SAMUEL L.;SHEPARD, KENNETH L.;ANDERSON, PAUL S.;BALDWIN, JOHN J.;+, J. MED. CHEM., 32,(1989) N2, C. 2548-2554
  作者：GRAHAM, SAMUEL L.、SHEPARD, KENNETH L.、ANDERSON, PAUL S.、BALDWIN, JOHN J.、+

  DOI：——

  日期：——
• OCULAR DRUG DELIVERY DEVICES
  申请人：Aton Pharma, Inc.

  公开号：EP2493459A1

  公开（公告）日：2012-09-05
• OCULAR STRIPS
  申请人：LIM Johnson

  公开号：US20120213840A1

  公开（公告）日：2012-08-23

  Ocular inserts including a cylindrical body, a lumen and a hydrophilic polymer and strips thereof are suitable for contact with an eye of a subject suffering from an eye disorder. While in contact with an eye, the ocular inserts may be used for releasing various agents, including pharmaceutically active agents, and effecting a treatment of one or more eye disorders.