N-[2-(methanesulfonamido)ethyl]benzenesulfonamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[2-(methanesulfonamido)ethyl]benzenesulfonamide
• 化学式: C₉H₁₄N₂O₄S₂
• mdl: MFCD02973506
• 分子量: 278.4
• InChiKey: PXHJXRVHSBOBAV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  109
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Sulphonamides
  申请人：JOHN WYETH & BROTHER LIMITED

  公开号：EP0213793B1

  公开（公告）日：1992-03-18
• 3-INDOL SUBSTITUTED DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE
  申请人：Pfizer Inc.

  公开号：EP3334733A1

  公开（公告）日：2018-06-20
• [EN] 3-INDOL SUBSTITUTED DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE<br/>[FR] DÉRIVÉS SUBSTITUÉS PAR UN 3-INDOLE, COMPOSITIONS PHARMACEUTIQUES ET LEURS PROCÉDÉS D'UTILISATION
  申请人：PFIZER

  公开号：WO2017025868A1

  公开（公告）日：2017-02-16

  A compound of Formula (I) is provided: or pharmaceutically acceptable enantiomers, salts or solvates thereof. The invention further relates to the use of the compounds of Formula (I) as TD02 inhibitors. The invention also relates to the use of the compounds of Formula I for the treatment and/or prevention of cancer, neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease and Huntington's disease, chronic viral infections such as HCV and HIV, depression, and obesity. The invention also relates to a process for manufacturing compounds of Formula (I).