6-苯并呋喃-2-基-1H-吲哚 | 885273-43-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 2-芳基苯并呋喃类黄酮
• 中文名称: 6-苯并呋喃-2-基-1H-吲哚
• 中文别名: 1-(苯并呋喃-2-基)-1H-吲哚
• 英文名称: 6-Benzofuran-2-YL-1H-indole
• 英文别名: 6-(1-benzofuran-2-yl)-1H-indole
• CAS: 885273-43-8
• 化学式: C₁₆H₁₁NO
• 分子量: 233.26
• InChiKey: ZFIYCYQDWRZIPU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  28.9
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2934999090

文献信息

• Novel 2-Heteroaryl Substituted Benzothiophenes and Benzofuranes 709
  申请人：Arzel Erwan

  公开号：US20080221149A1

  公开（公告）日：2008-09-11

  The present invention relates to novel 2-heteroaryl substituted benzothiophene and benzofuran derivatives, precursors thereof, and therapeutic uses of such compounds, having the structural formula (Ia) below: and to their pharmaceutically acceptable salt, compositions and methods of use. Furthermore, the invention relates to novel 2-heteroaryl substituted benzothiophene and benzofuran derivatives that are suitable for imaging amyloid deposits in living patients, their compositions, methods of use and processes to make such compounds. More specifically, the present invention relates to a method of imaging amyloid deposits in brain in vivo to allow antemortem diagnosis of Alzheimer's disease as well as measureing clinical efficacy of Alzheimer's disease therapeutic agents.

  本发明涉及新型2-杂环芳基取代苯并噻吩和苯并呋喃衍生物，其前体以及这些化合物的治疗用途，具有如下结构式(Ia)： 以及它们的药用盐、组合物和使用方法。此外，本发明涉及适用于在活体患者中成像淀粉样沉积物的新型2-杂环芳基取代苯并噻吩和苯并呋喃衍生物，它们的组合物、使用方法以及制备这类化合物的过程。更具体地，本发明涉及一种在体内成像脑部淀粉样沉积物的方法，以允许在死前诊断阿尔茨海默病，并测量阿尔茨海默病治疗药物的临床疗效。
• Novel modulators of potassium channels
  申请人：4SC AG

  公开号：US20030203959A1

  公开（公告）日：2003-10-30

  The invention relates to the use of a compound of the Formula (I) 1 or a salt, a physiologically functional derivative, or a prodrug thereof as a medicament, wherein R is a monocyclic or polycyclic substituted or unsubstituted aromatic ring system which may contain one or more groups X and which contains at least one aromatic ring; X is selected from the group consisting of S, O, N, NR′, SO or SO 2 ; R is optionally substituted by one to four substituents which are independently selected from the group consisting of halogen, CF 3 , OCF 3 , alkyl, cycloalkyl, haloalkyl, haloalkyloxy, hydroxyalkyl, hydroxyalkylamine, amine, aminoalkyl, alkylamine, CR′O, CO 2 R′, alkoxy, alkylthio, alkylaryl, alkylsulfonyl, H, hydroxy, aryl, heteroaryl, —NR′OR′, CN, alkylsulfinyl, arylsulfonyl, heteroarylsulfonyl, SO 3 R′, NO 2 , —CO—NR′R 1 , arylalkyl-O—, —O-aryl, —O-heteroaryl, arylalkyl-S—, —S-aryl, —S-heteroaryl, —NR 1 —SO 2 R′, —SO 2 —NR I -alkyl, —SO 2 —NR 1 -aryl, and —SO 2 —N 1 -heteroaryl.

  本发明涉及式（I）化合物的用途 1 或其盐、生理功能衍生物或其原药作为药物，其中 R 是单环或多环取代或未取代的芳香环系统，可包含一个或多个基团 X，且至少包含一个芳香环； X 选自 S、O、N、NR′、SO 或 SO 2 ; R 可任选被一至四个取代基取代，这些取代基独立地选自由卤素、CF 3 、OCF 3 烷基、环烷基、卤代烷基、卤代烷氧基、羟基烷基、羟基烷基胺、胺、氨基烷基、烷基胺、CR′O、CO 2 R′、烷氧基、烷硫基、烷芳基、烷基磺酰基、H、羟基、芳基、杂芳基、-NR′OR′、CN、烷基亚磺酰基、芳基磺酰基、杂芳基磺酰基、SO 3 R′、NO 2 、-CO-NR′R 1 ，芳烷基-O-，-O-芳基，-O-杂芳基，芳烷基-S-，-S-芳基，-S-杂芳基，-NR 1 -SO 2 R′、-SO 2 -NR I -烷基、-SO 2 -NR 1 -芳基和 -SO 2 -N 1 -杂芳基。
• US7772256B2
  申请人：——

  公开号：US7772256B2

  公开（公告）日：2010-08-10