2-nitrobenzoyl bromide | 151093-39-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-nitrobenzoyl bromide
• CAS: 151093-39-9
• 化学式: C₇H₄BrNO₃
• 分子量: 230.018
• InChiKey: KLDYYWMVZQWEGY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  62.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  二氢丁香酚 、 2-nitrobenzoyl bromide 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Synthesis and Anti‐Oomycete Activity of 1‐Sulfonyloxy/Acyloxydihydroeugenol Derivatives

  摘要：

  AbstractEndeavor to discover biorational natural products‐based fungicides, two series (26) of novel 1‐sulfonyloxy/acyloxydihydroeugenol derivatives (3a–p and 5a–j) were prepared and assessed for their fungicidal activity against P. capsici Leonian, in vitro. Results of fungicidal activity revealed that, among all compounds, especially compounds 3a, 5c, and 5e displayed the most potent anti‐oomycete activity against P. capsici with EC50 values of 69.33, 68.81, and 67.77 mg/L, respectively. Overall, the anti‐oomycete activities of 1‐acyloxydihydroeugenol derivatives (5a–j) were higher than that of 1‐sulfonyloxydihydroeugenol derivatives (3a–p). It is proved that the introduction of the acyl group at hydroxy position of dihydroeugenol is more beneficial to improve its anti‐oomycete activity than that of the sulfonyl group. These preliminary results will pave the way for further modification of dihydroeugenol in the development of potential new fungicides.

  DOI：

  10.1002/cbdv.202100329
• 作为产物：
  描述：

  邻硝基苯甲酸 在 三溴甲基苯砜 、 三苯基膦 作用下， 以 二氯甲烷 为溶剂， 生成 2-nitrobenzoyl bromide
  参考文献：
  名称：

  新型 1-磺酰氧基/酰氧基丁香酚衍生物作为杀菌剂的组合合成

  摘要：

  背景： 开发高效、低风险的小分子绿色杀菌剂是有效控制植物病原真菌的关键。精油因其独特的来源和潜在的靶点，在新型杀菌剂发现中发挥着非常重要的作用。丁香酚是一种植物精油，主要从桃金娘科的丁香属植物的未开放和干燥的花蕾中分离得到。由于其独特的结构骨架，丁香酚及其衍生物展现出了广泛的生物活性。然而，关于合成新型1-磺酰氧基/酰氧基丁香酚衍生物作为对辣椒疫霉菌的杀菌剂的研究尚未报道。 方法： 制备了26种新型1-磺酰氧基/酰氧基丁香酚衍生物（3a-p和5a-j），并通过1H NMR、HRMS和熔点对其结构进行了良好的表征。使用菌丝生长速率法评估了它们对辣椒疫霉菌的杀菌活性。 结果： 为了寻找控制植物病原真菌的新型天然产物杀菌剂，我们设计和合成了两系列新型1-磺酰氧基/酰氧基丁香酚衍生物（3a-p和5a-j）作为对辣椒疫霉菌的杀菌剂。杀菌活性结果显示，在所有化合物中，特别是化合物3a、3f和3n，对辣椒疫霉菌的抗真菌活性最强，EC50值分别为79.05、75.05和70.80。 结论： 结果表明，磺酰氧基的丁香酚的抗真菌活性高于酰氧基。建议通过引入磺酰氧基来提高丁香酚的杀菌活性。这将为进一步设计、结构修饰和开发丁香酚衍生物作为杀菌剂铺平道路。

  DOI：

  10.2174/1386207324666210813114829

文献信息

• [EN] PREPARATION OF PROSTAGLANDIN DERIVATIVES<br/>[FR] PRÉPARATION DE DÉRIVÉS DE PROSTAGLANDINES
  申请人：APTUIT LAURUS PRIVATE LTD

  公开号：WO2012011128A1

  公开（公告）日：2012-01-26

  A process for preparing the prostaglandin derivatives is provided, wherein the benzoyl and p-nitrobenzoyl groups are used as the hydroxyl protective groups. A pharmaceutical composition comprising the prostaglandin derivatives is also provided.

  提供了一种制备前列腺素衍生物的过程，其中苯甲酰和对硝基苯甲酰基被用作羟基保护基团。同时还提供了一种包含前列腺素衍生物的药物组合物。
• Bis-[aminophenyl ketones] compounds
  申请人：Air Products and Chemicals, Inc.

  公开号：US05072046A1

  公开（公告）日：1991-12-10

  This invention relates to a process for producing bis-[aminophenyl ketones] and the resulting compositions which are suitable for the preparation of engineering polymers, e.g., polyimides, polyurethanes and a host of other resinous materials. The bis-[aminophenyl ketones] are formed by reacting 2 moles of a nitrophenyl acid halide with an aromatic bridging composition having at least two hydrogen atoms of sufficient reactivity to undergo acylation reactions whereby nitrophenyl ketone groups are attached to the aromatic bridging group. The resulting bis-[nitrophenyl ketones] then are converted to the amine by hydrogenation or by double nucleophilic displacement with an aminophenol. The invention also relates to polyimides and polyamides prepared from such bis-[aminophenyl ketones].

  本发明涉及一种生产双[氨基苯酮]及其产生的组合物的工艺，该组合物适用于制备工程聚合物，例如聚酰亚胺，聚氨酯和大量其他树脂材料。双[氨基苯酮]是通过将2摩尔的硝基苯酸卤与至少具有足够反应性以进行酰化反应的两个氢原子的芳香桥接组合物反应而形成的，从而将硝基苯酮基团连接到芳香桥接基团上。然后，通过氢化或通过与氨基酚的双亲核取代将产生的双[硝基苯酮]转化为胺。本发明还涉及从这种双[氨基苯酮]制备的聚酰亚胺和聚酰胺。
• Orthogonal translation components for the in vivo incorporation of unnatural amino acids
  申请人：The Scripps Research Institute

  公开号：EP2383340A2

  公开（公告）日：2011-11-02

  The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate unnatural amino acids into proteins produced in eubacterial host cells such as E.coli, or in a eukaryotic host such as a yeast cell. The invention provides, for example but not limited to, novel orthogonal synthetases, methods for identifying and making the novel synthetases, methods for producing proteins containing unnatural amino acids, and translation systems.

  本发明涉及正交对 tRNA 和氨基酰-tRNA 合成酶，它们可以将非天然氨基酸掺入到在真细菌宿主细胞（如大肠杆菌）或真核细胞宿主（如酵母细胞）中生产的蛋白质中。本发明提供了例如但不限于新型正交合成酶、鉴定和制造新型合成酶的方法、生产含有非天然氨基酸的蛋白质的方法以及翻译系统。
• HETEROCYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING ELEMENT USING SAME
  申请人：Heesung Material Ltd.

  公开号：EP3214085A2

  公开（公告）日：2017-09-06

  The present specification relates to a novel hetero-cyclic compound and an organic light emitting device using the same.

  本说明书涉及一种新型杂环化合物和使用该化合物的有机发光器件。
• POLYMER, PHOTOSENSITIVE RESIN COMPOSITION, PATTERNING METHOD, METHOD OF FORMING CURED FILM, INTERLAYER INSULATING FILM, SURFACE PROTECTIVE FILM, AND ELECTRONIC COMPONENT
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：EP3896521A1

  公开（公告）日：2021-10-20

  Provided is a polymer that can be used as a base resin for a positive photosensitive resin composition and a negative photosensitive resin composition, wherein the positive photosensitive resin composition and the negative photosensitive resin composition are soluble in an aqueous alkaline solution, can form a fine pattern, can achieve high resolution, and have good mechanical properties even when they are cured at low temperature. Also provided are a positive photosensitive resin composition and a negative photosensitive resin composition using the polymer. The polymer is represented by general formulas (1) and/or (2): wherein T1 and T2 may be the same as, or different from, each other and represent any of -CO- and -SO2-; X1 is a tetravalent organic group; and 1 is 0 or 1; and X2 is a divalent organic group.

  本发明提供了一种聚合物，可用作正感光树脂组合物和负感光树脂组合物的基础树脂，其中正感光树脂组合物和负感光树脂组合物可溶于碱性水溶液，可形成精细图案，可实现高分辨率，即使在低温下固化也具有良好的机械性能。此外，还提供了使用该聚合物的正感光树脂组合物和负感光树脂组合物。该聚合物由通式（1）和/或（2）表示： 其中 T1 和 T2 可以彼此相同或不同，并代表 -CO- 和 -SO2- 中的任何一种；X1 是四价有机基团；1 是 0 或 1；X2 是二价有机基团。