2,5-dioxopyrrolidin-1-yl 1-(4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl)-3-oxo-6,9,12,15,18-pentaoxa-2-azahenicosan-21-oate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四嗪
• 英文名称: 2,5-dioxopyrrolidin-1-yl 1-(4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl)-3-oxo-6,9,12,15,18-pentaoxa-2-azahenicosan-21-oate
• 英文别名: Me-Tet-PEG5-NHS；(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[3-[[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]methylamino]-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
• 化学式: C₂₈H₃₈N₆O₁₀
• 分子量: 618.644
• InChiKey: WIMBDRIDFKMKOO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  44
• 可旋转键数：
  23
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  191
• 氢给体数：
  1
• 氢受体数：
  14

反应信息

• 作为反应物：
  描述：

  、 2,5-dioxopyrrolidin-1-yl 1-(4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl)-3-oxo-6,9,12,15,18-pentaoxa-2-azahenicosan-21-oate 在 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以2.3 mg的产率得到3',6'-bis(dimethylamino)-N-[2-[3-[2-[2-[2-[2-[3-[[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]methylamino]-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoylamino]ethyl]-3-oxospiro[2-benzofuran-1,9'-xanthene]-5-carboxamide
  参考文献：
  名称：

  STEPWISE ASSEMBLED CAPTURE COMPOUNDS COMPRISING A CLEAVABLE FUNCTION AND METHOD FOR ISOLATING AND/OR CHARACTERIZING BIOMOLECULES OR BIOMOLECULE FRAGMENTS, IN PARTICULAR PROTEINS OR PROTEIN FRAGMENTS, OF COMPLEX MIXTURES

  摘要：

  该发明涉及一种用于分离和/或表征生物分子和/或生物分子片段的过程，特别是蛋白质和/或蛋白质片段，包括以下步骤：通过捕获化合物CC与目标化合物T以及携带化合物CCB相互作用提供固定化合物IC，进行分割步骤，在该步骤中，可切割功能F被切割，产生分割化合物DC，并分离和/或表征该分割化合物DC。该发明还涉及携带化合物CCB、捕获化合物CC、前体化合物PC和分割化合物DC。

  公开号：

  US20160349268A1

文献信息

• Stepwise assembled capture compounds comprising a cleavable function and method for isolating and/or characterizing biomolecules or biomolecule fragments, in particular proteins or protein fragments, of complex mixtures
  申请人：Caprotec Bioanalytics GmbH

  公开号：EP2913674A1

  公开（公告）日：2015-09-02

  The invention relates to a process for isolating and/or characterising biomolecules and/or biomolecule fragments, in particular proteins and/or protein fragments, comprising the steps: provision of an immobilized compound IC through the interaction of a capture compound CC and the target compound T and a carrier compound CCB, carrying out a division step, in which a cleavable function F is cleaved, and a division compound DC is produced, and isolation and/or characterisation of said division compound DC. The invention relates further to a carrier compound CCB, a capture compound CC, a precursor compound PC and a division compound DC.

  本发明涉及一种分离和/或鉴定生物大分子和/或生物大分子片段，特别是蛋白质和/或蛋白质片段的工艺，包括以下步骤： 通过捕获化合物 CC 和目标化合物 T 以及载体化合物 CCB 的相互作用提供固定化化合物 IC，进行分裂步骤，其中可裂解功能 F 被裂解，产生分裂化合物 DC，以及 分离和/或表征所述分裂化合物 DC。本发明还涉及一种载体化合物 CCB、一种捕获化合物 CC、一种前体化合物 PC 和一种分裂化合物 DC。
• [EN] STEPWISE ASSEMBLED CAPTURE COMPOUNDS COMPRISING A CLEAVABLE FUNCTION AND METHOD FOR ISOLATING AND/OR CHARACTERIZING BIOMOLECULES OR BIOMOLECULE FRAGMENTS, IN PARTICULAR PROTEINS OR PROTEIN FRAGMENTS, OF COMPLEX MIXTURES<br/>[FR] COMPOSÉS DE CAPTURE ASSEMBLÉS PAR ÉTAPES COMPRENANT UNE FONCTION CLIVABLE ET PROCÉDÉ POUR ISOLER ET/OU CARACTÉRISER DES BIOMOLÉCULES OU DES FRAGMENTS DE BIOMOLÉCULES, EN PARTICULIER DES PROTÉINES OU DES FRAGMENTS DE PROTÉINES, DE MÉLANGES COMPLEXES
  申请人：CAPROTEC BIOANALYTICS GMBH

  公开号：WO2015114023A1

  公开（公告）日：2015-08-06

  The invention relates to a process for isolating and/or characterising biomolecules and/or biomolecule fragments, in particular proteins and/or protein fragments, comprising the steps: provision of an immobilized compound IC through the interaction of a capture compound CC and the target compound T and a carrier compound CCB, carrying out a division step, in which a cleavable function F is cleaved, and a division compound DC is produced, and isolation and/or characterisation of said division compound DC. The invention relates further to a carrier compound CCB, a capture compound CC, a precursor compound PC and a division compound DC.
• STEPWISE ASSEMBLED CAPTURE COMPOUNDS COMPRISING A CLEAVABLE FUNCTION AND METHOD FOR ISOLATING AND/OR CHARACTERIZING BIOMOLECULES OR BIOMOLECULE FRAGMENTS, IN PARTICULAR PROTEINS OR PROTEIN FRAGMENTS, OF COMPLEX MIXTURES
  申请人：CAPROTEC BIOANALYTICS GMBH

  公开号：US20160349268A1

  公开（公告）日：2016-12-01

  The invention relates to a process for isolating and/or characterising biomolecules and/or biomolecule fragments, in particular proteins and/or protein fragments, comprising the steps: provision of an immobilized compound IC through the interaction of a capture compound CC and the target compound T and a carrier compound CCB, carrying out a division step, in which a cleavable function F is cleaved, and a division compound DC is produced, and isolation and/or characterisation of said division compound DC. The invention relates further to a carrier compound CCB, a capture compound CC, a precursor compound PC and a division compound DC.

  该发明涉及一种用于分离和/或表征生物分子和/或生物分子片段的过程，特别是蛋白质和/或蛋白质片段，包括以下步骤：通过捕获化合物CC与目标化合物T以及携带化合物CCB相互作用提供固定化合物IC，进行分割步骤，在该步骤中，可切割功能F被切割，产生分割化合物DC，并分离和/或表征该分割化合物DC。该发明还涉及携带化合物CCB、捕获化合物CC、前体化合物PC和分割化合物DC。