N-[2-(3-chlorophenyl)ethyl]-4-pyridin-4-ylbenzamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N-[2-(3-chlorophenyl)ethyl]-4-pyridin-4-ylbenzamide
• 化学式: C₂₀H₁₇ClN₂O
• 分子量: 336.8
• InChiKey: UVLYYEJRFZZWBD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  42
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• COMPOUNDS FOR COGNITIVE ENHANCEMENT AND METHODS OF USE THEREOF
  申请人：The Translational Genomics Research Institute

  公开号：US20160272587A1

  公开（公告）日：2016-09-22

  The invention provides compounds that inhibit ROCK activity. In certain embodiments the compounds of the invention enhance cognitive function. The invention is also directed to pharmaceutical compositions that comprise ROCK inhibitors and to methods enhance cognitive function and reducing and/or treat cognitive function decline.
• US9617214B2
  申请人：——

  公开号：US9617214B2

  公开（公告）日：2017-04-11
• [EN] COMPOUNDS FOR COGNITIVE ENHANCEMENT AND METHODS OF USE THEREOF<br/>[FR] COMPOSÉS D'AMÉLIORATION NEURO-COGNITIVE ET MÉTHODES D'UTILISATION ASSOCIÉES
  申请人：TRANSLATIONAL GENOMICS RES INST

  公开号：WO2015070170A1

  公开（公告）日：2015-05-14

  The invention provides compounds that inhibit ROCK activity. In certain embodiments the compounds of the invention enhance cognitive function. The invention is also directed to pharmaceutical compositions that comprise ROCK inhibitors and to methods enhance cognitive function and reducing and/or treat cognitive function decline.