4,4,4',4',5,5'-Hexamethyl-2,2'-bi-1,3,2-dioxaborolane | 230299-51-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 溴苄基硼酸频哪醇酯
• 英文名称: 4,4,4',4',5,5'-Hexamethyl-2,2'-bi-1,3,2-dioxaborolane
• 英文别名: 4,4,5-trimethyl-2-(4,4,5-trimethyl-1,3,2-dioxaborolan-2-yl)-1,3,2-dioxaborolane
• CAS: 230299-51-1
• 化学式: C₁₀H₂₀B₂O₄
• 分子量: 225.888
• InChiKey: BUYDMXHVALZHGU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.47
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4,4,4',4',5,5'-Hexamethyl-2,2'-bi-1,3,2-dioxaborolane 、 tert-butyl 4-(7-bromoquinolin-2-yl)piperidine-1-carboxylate 在 (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride 、 potassium acetate 作用下， 以 1,4-二氧六环 为溶剂， 反应 0.67h， 生成 tert-butyl 4-(7-(4,4,5-trimethyl-1,3,2-dioxaborolan-2-yl)quinolin-2-yl)-piperidine-1-carboxylate
  参考文献：
  名称：

  [EN] ANTIDIABETIC BICYCLIC COMPOUNDS
  [FR] COMPOSÉS BICYCLIQUES ANTIDIABÉTIQUES

  摘要：

  结构式(I)的新型化合物及其药用盐是G蛋白偶联受体40（GPR40）的激动剂，可能在治疗、预防和抑制由G蛋白偶联受体40介导的疾病中有用。本发明的化合物可能在治疗2型糖尿病以及与该疾病常见相关的疾病，包括肥胖和脂质紊乱（如混合型或糖尿病性脂质代谢异常、高脂血症、高胆固醇血症和高甘油三酯血症）方面有用。

  公开号：

  WO2017172505A1

文献信息

• Substituted 1,3-Benzothiazol-2(3H)-Ones and [1,3]Thiazolo[5,4-B]Pyridin-2(IH)-Ones as Positive Allosteric Modulators of MGLUR2
  申请人：Layton Mark E.

  公开号：US20130035332A1

  公开（公告）日：2013-02-07

  The present invention is directed to benzothiazol-one and thiazolo pyridine-one derivatives which are potentiators of metabotropic glutamate receptors, particularly the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.

  本发明涉及苯并噻唑-1和噻唑吡啶-1衍生物，它们是代谢型谷氨酸受体增强剂，特别是mGluR2受体的增强剂，并且在治疗或预防与谷氨酸功能障碍有关的神经和精神障碍以及代谢型谷氨酸受体参与的疾病方面具有用途。本发明还涉及包含这些化合物的制药组合物以及这些化合物和组合物在预防或治疗代谢型谷氨酸受体参与的疾病方面的用途。
• SUBSTITUTED 1,3-BENZOTHIAZOL-2(3H)-ONES AND [1,3]THIAZOLO[5,4-B]PYRIDIN-2(1H)-ONES AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2
  申请人：LAYTON MARK E.

  公开号：US20140045829A1

  公开（公告）日：2014-02-13

  The present invention is directed to benzothiazol-one and thiazolo pyridine-one derivatives which are potentiators of metabotropic glutamate receptors, particularly the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.

  本发明涉及苯并噻唑酮和噻唑吡啶酮衍生物，它们是代谢型谷氨酸受体的增强剂，特别是mGluR2受体，并且它们在治疗或预防与谷氨酸功能障碍有关的神经和精神障碍以及代谢型谷氨酸受体参与的疾病中非常有用。本发明还涉及包含这些化合物的制药组合物以及在预防或治疗代谢型谷氨酸受体参与的这些疾病中使用这些化合物和组合物。
• POSITIVE ALLOSTERIC MODULATORS OF MGLUR2
  申请人：Layton Mark E.

  公开号：US20130158002A1

  公开（公告）日：2013-06-20

  The present invention is directed to 5-substituted 1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide and 1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridine 2,2,-dioxide derivatives which are potentiators of metabotropic glutamate receptors, particularly the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.

  本发明涉及5-取代的1,3-二氢-2,1,3-苯并噻二唑2,2-二氧化物和1,3-二氢[1,2,5]噻二唑并[3,4-b]吡啶2,2-二氧化物衍生物，它们是代谢型谷氨酸受体的增强剂，特别是mGluR2受体，并且可用于治疗或预防与谷氨酸功能障碍相关的神经和精神障碍以及代谢型谷氨酸受体参与的疾病。本发明还涉及包含这些化合物的药物组合物以及在预防或治疗代谢型谷氨酸受体参与的疾病中使用这些化合物和组合物。
• Substituted 1,3-benzothiazol-2(3H)-ones and [1,3]thiazolo[5,4-B]pyridin-2(1H)-ones as positive allosteric modulators of mGluR2
  申请人：Merck Sharp & Dohme Corp.

  公开号：US08952005B2

  公开（公告）日：2015-02-10

  The present invention is directed to benzothiazol-one and thiazolo pyridine-one derivatives which are potentiators of metabotropic glutamate receptors, particularly the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.

  本发明涉及苯并噻唑-1和噻唑吡啶-1衍生物，它们是代谢性谷氨酸受体的增强剂，特别是mGluR2受体，并且它们在治疗或预防与谷氨酸功能障碍有关的神经和精神障碍以及与代谢性谷氨酸受体有关的疾病方面非常有用。本发明还涉及包含这些化合物的制药组合物以及在预防或治疗涉及代谢性谷氨酸受体的疾病方面使用这些化合物和组合物。
• Positive allosteric modulators of mGluR2
  申请人：Layton Mark E.

  公开号：US09108937B2

  公开（公告）日：2015-08-18

  The present invention is directed to 5-substituted 1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide and 1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridine 2,2,-dioxide derivatives which are potentiators of metabotropic glutamate receptors, particularly the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.

  本发明涉及5-取代的1,3-二氢-2,1,3-苯并噻二唑2,2-二氧化物和1,3-二氢[1,2,5]噻二唑并[3,4-b]吡啶2,2-二氧化物衍生物，它们是代谢型谷氨酸受体（尤其是mGluR2受体）的增强剂，可用于治疗或预防与谷氨酸功能障碍相关的神经和精神障碍以及代谢型谷氨酸受体参与的疾病。本发明还涉及包含这些化合物的制药组合物以及这些化合物和组合物在预防或治疗代谢型谷氨酸受体参与的疾病中的使用。