N-[4-[2,5-dioxo-1-[4-(trifluoromethoxy)phenyl]pyrrolidin-3-yl]phenyl]-2,2,2-trifluoroacetamide | 499782-94-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: N-[4-[2,5-dioxo-1-[4-(trifluoromethoxy)phenyl]pyrrolidin-3-yl]phenyl]-2,2,2-trifluoroacetamide
• CAS: 499782-94-4
• 化学式: C₁₉H₁₂F₆N₂O₄
• 分子量: 446.3
• InChiKey: DPDKKGBZJQACOR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  75.7
• 氢给体数：
  1
• 氢受体数：
  10

文献信息

• Inhibition of RNA function
  申请人：The Regents of the University of California

  公开号：US20030229082A1

  公开（公告）日：2003-12-11

  Inhibition of RNA function, and treatment or control of diseases or conditions, e.g. infectious diseases such as viruses and viral infections (including HIV) and microbial infections, by the contacting of the RNA with a compound having a central or core structure comprising three fused rings containing from 12 to 15 ring atoms, the central ring including at least one heteroatom selected from nitrogen, oxygen and sulfur, the atoms of the three-ring core structure being optionally substituted with substituents such as halogens, cyano, and/or various substituted or unsubstituted aliphatic and/or heteroaliphatic moieties, or contacting the RNA with yohimbine, usnic acid or N-{4-[2,5-Dioxo-1-(4-trifluoromethoxy-phenyl)-pyrrolidin-3-yl]-phenyl}-2,2,2-trifluoro-acetamide. Preferred compounds are various phenothiazines, including both known and novel compounds.

  抑制RNA功能，并通过将RNA与含有由12至15个环原子的三个融合环组成的中心或核结构的化合物接触，来治疗或控制疾病或病况，例如传染病如病毒和病毒感染（包括HIV）以及微生物感染，其中中心环至少包括一种氮、氧或硫等杂原子，三环核结构的原子可选择性地取代为卤素、氰基和/或各种取代或未取代的脂肪和/或杂原脂肪基，或者将RNA与鹿胶碱、乌斯尼酸或N-[4-(2,5-二氧代-1-(4-三氟甲氧基苯基)-吡咯啉-3-基)-苯基]-2,2,2-三氟乙酰胺接触。优选的化合物包括各种吩噻嗪，包括已知和新颖的化合物。
• MITTEL ZUR THERAPIE VON MENSCHLICHEN ERKRANKUNGEN, INSBESONDERE FÜR DIE THERAPIE VON TUMOREN WIE KOLONKARZINOMEN UND MELANOMEN ODER ZUR GEWEBEREGENERATION UND FÖRDERUNG DES HAARWUCHSES
  申请人：MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

  公开号：EP1214345B1

  公开（公告）日：2004-12-29
• US7067474B1
  申请人：——

  公开号：US7067474B1

  公开（公告）日：2006-06-27
• [EN] INHIBITION OF RNA FUNCTION<br/>[FR] INHIBITION DE FONCTION ARN
  申请人：UNIV CALIFORNIA

  公开号：WO2003062388A2

  公开（公告）日：2003-07-31

  Inhibition of RNA function, and treatment or control of associated diseases or conditions, e.g. infectious diseases such as viruses and viral infections (including HIV) and microbial infections, is inhibited by the use contacting of the RNA with of a compound having a central or core structure comprising three fused rings containing from 12 to 15 ring atoms, the central ring including at least one heteroatom selected from nitrogen, oxygen and sulfur, the atoms of the three-ring core structure being optionally substituted with substituents such as halogens, cyano, and/or various substituted or unsubstituted aliphatic and/or heteroaliphatic moieties, or contacting the RNA with yohimbine, usnic acid or N-4-[2,5-Dioxo-1-(4-trifluoromethoxy-phenyl)-pyrrolidin-3-yl]-phenyl}-2,2,2-trifluoro-acetamide. Preferred compounds are various phenothiazines, including both known and novel compounds.