2,4-bis-acetylamino-6-methyl-[1,3,5]triazine | 30355-54-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2,4-bis-acetylamino-6-methyl-[1,3,5]triazine
• 英文别名: N,N'-(methyl-[1,3,5]triazine-2,4-diyl)-bis-acetamide；N,N'-(Methyl-[1,3,5]triazin-2,4-diyl)-bis-acetamid；N,N'-(6-methyl-1,3,5-triazine-2,4-diyl)diacetamide；N-(4-acetamido-6-methyl-1,3,5-triazin-2-yl)acetamide
• CAS: 30355-54-5
• 化学式: C₈H₁₁N₅O₂
• mdl: MFCD02181814
• 分子量: 209.208
• InChiKey: SAGCVQBYKLYTBS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.375
• 拓扑面积：
  96.9
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2,4-bis-acetylamino-6-methyl-[1,3,5]triazine 、 溶剂黄146 生成 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  Ostrogovich, Chemisches Zentralblatt, 1905, vol. 76, # II, p. 1359

  摘要：

  DOI：
• 作为产物：
  描述：

  2,4-二氨基-6-甲基-1,3,5-三嗪 、 乙酸酐 生成 2,4-bis-acetylamino-6-methyl-[1,3,5]triazine
  参考文献：
  名称：

  Grundmann; Beyer, Chemische Berichte, 1950, vol. 83, p. 452,453

  摘要：

  DOI：

文献信息

• THE REACTION OF ACETIC AND TRIFLUOROACETIC ANHYDRIDES WITH SOME SUBSTITUTED GUANIDINE HYDROCHLORIDES
  作者：W. F. Cockburn、R. A. B. Bannard

  DOI：10.1139/v57-171

  日期：1957.11.1

  Acetylation of the hydrochlorides of guanidine, cyclohexylguanidine, and 1-guanylpiperidine has been found to yield substituted triazines. Trifluoroacetylation of 1-guanylpiperidine hydrochloride also gives a triazine, whereas guanidine hydrochloride and cyclohexylguanidine hydrochloride are converted to bistrifluoroacetyl derivatives. The same triazines can also be obtained by acylation of the appropriate

  已经发现胍、环己基胍和1-胍基哌啶的盐酸盐的乙酰化产生取代的三嗪。1-胍基哌啶盐酸盐的三氟乙酰化也产生三嗪，而胍盐酸盐和环己基胍盐酸盐转化为双三氟乙酰基衍生物。同样的三嗪也可以通过适当的双胍酰化得到。
• Chemical and Chemotherapeutical Studies on the Furan Derivatives. XXXVIII. Synthesis and Antitumor Effect of Methylol Derivatives of Nitrofurylvinyl-Aminoheterocyclics
  作者：koji Miura、Masao Ikeda、Tomiji Oohashi、Yoshiko Igarashi、Ikuko Okada

  DOI：10.1248/cpb.13.529

  日期：——

  Six methylol derivatives of nitrofurylvinylogues were prepared from their parent compounds with formaldehyde or paraformaldehyde in water or in organic solvents. Of these, antitumor effect on Ehrlich ascites carcinoma in mice was investigated. 2-Bis(hydroxymethyl)amino-4-[2-(5-nitro-2-furyl) vinyl] pyrimidine (D-ran-methylol) and 2-bis(hydroxymethyl)amino-4-[2-(5-nitro-2-furyl) vinyl] quinoline (2A-4Q-ran-methylol) were revealed to save mice completely from tumor death with the suitable dose intraperitoneally. These two compounds had small toxicities and administrations of 1, 000 mg. per kilo did not kill any mouse.

  在水或有机溶剂中，用甲醛或多聚甲醛从其母体化合物制备了六种硝基糠醛基乙烯基醚的甲醇衍生物。研究了这些衍生物对小鼠艾氏腹水癌的抗肿瘤作用。结果表明，腹腔注射适当剂量的 2-双（羟甲基）氨基-4-[2-（5-硝基-2-呋喃基）乙烯基]嘧啶（D-ran-methylol）和 2-双（羟甲基）氨基-4-[2-（5-硝基-2-呋喃基）乙烯基]喹啉（2A-4Q-ran-methylol）可使小鼠完全免于肿瘤死亡。这两种化合物的毒性较小，每公斤 1,000 毫克的剂量不会导致任何小鼠死亡。
• Rjabinin, Zhurnal Obshchei Khimii, 1952, vol. 22, p. 541; engl. Ausg. S. 605
  作者：Rjabinin

  DOI：——

  日期：——
• HUMIDITY DEPENDENCE IMPROVER FOR POLYMER FILM, POLYMER FILM, PROTECTIVE FILM FOR POLARIZER, RETARDATION FILM, POLARIZER, AND LIQUID CRYSTAL DISPLAY DEVICE
  申请人：Yasuda Takayasu

  公开号：US20110073007A1

  公开（公告）日：2011-03-31

  A humidity dependence improver for polymer film, comprising a compound of the following formula (1) or (2): wherein Ra, Rb and Rc represent an alkyl group, an alkenyl group, an alkynyl group, an aryl group or a heterocyclic group; X 1 to X 6 represent a single bond or a divalent linking group; R 1 to R 6 represent a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group, an aryl group or a heterocyclic group.
• US8465673B2
  申请人：——

  公开号：US8465673B2

  公开（公告）日：2013-06-18