(3R,4S,7S,9S,11S)-3,4,11-trihydroxy-7-[(Z,4R)-4-(hydroxymethyl)hex-2-en-2-yl]-9-methoxy-12,12-dimethyl-6-oxabicyclo[11.3.1]heptadeca-1(17),13,15-trien-5-one

• 分子结构分类: 有机化合物 - 苯类化合物
• 英文名称: (3R,4S,7S,9S,11S)-3,4,11-trihydroxy-7-[(Z,4R)-4-(hydroxymethyl)hex-2-en-2-yl]-9-methoxy-12,12-dimethyl-6-oxabicyclo[11.3.1]heptadeca-1(17),13,15-trien-5-one
• 化学式: C₂₆H₄₀O₇
• 分子量: 464.6
• InChiKey: QQBSDIIBIDGOMZ-GJULWDICSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  33
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  116
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• [EN] PELORUSIDE ANALOGS<br/>[FR] ANALOGUES DE PÉLORUSIDE
  申请人：UNIV GENT

  公开号：WO2015079009A1

  公开（公告）日：2015-06-04

  The present invention provides new therapeutic compounds for treatment of diseases caused or influenced by microtubule stability, such as proliferative diseases. The compounds are phenyl-analogs of the naturally occurring peloruside. The analogs are easier to synthesize, and hence open up the possibility to produce said compounds in large quantities for therapeutic use.

  本发明提供了用于治疗由微管稳定性引起或影响的疾病，如增生性疾病的新治疗化合物。这些化合物是天然存在的佩洛鲁西德的苯类类似物。这些类似物更容易合成，因此打开了大规模生产这些化合物以供治疗使用的可能性。
• PELORUSIDE ANALOGS
  申请人：Universiteit Gent

  公开号：EP3074382B1

  公开（公告）日：2017-11-15
• Peloruside Analogs
  申请人：UNIVERSITEIT GENT

  公开号：US20160304483A1

  公开（公告）日：2016-10-20

  The present invention provides new therapeutic compounds for treatment of diseases caused or influenced by microtubule stability, such as proliferative diseases. The compounds are phenyl-analogs of the naturally occurring peloruside. The analogs are easier to synthesize, and hence open up the possibility to produce said compounds in large quantities for therapeutic use.
• US9771344B2
  申请人：——

  公开号：US9771344B2

  公开（公告）日：2017-09-26