N-hydroxysuccinimidyl-1-methoxypropane-3-carbonate | 160232-88-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: N-hydroxysuccinimidyl-1-methoxypropane-3-carbonate
• 英文别名: (2,5-Dioxopyrrolidin-1-yl) 3-methoxypropyl carbonate
• CAS: 160232-88-2
• 化学式: C₉H₁₃NO₆
• 分子量: 231.205
• InChiKey: QQICUDDDRFMZJQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  82.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  N-hydroxysuccinimidyl-1-methoxypropane-3-carbonate 、 1-hydroxybenzotriazole 在 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 72.0h， 生成 tert-butyl 4-((6-(((3-methoxypropoxy)carbonyl)amino)chroman-4-yl)methyl)-1H-imidazole-1-carboxylate
  参考文献：
  名称：

  WO2008/100459

  摘要：

  公开号：
• 作为产物：
  描述：

  N,N'-二琥珀酰亚胺基碳酸酯 、 3-甲氧基-1-丙醇 在 三乙胺 作用下， 以 乙腈 为溶剂， 反应 0.5h， 生成 N-hydroxysuccinimidyl-1-methoxypropane-3-carbonate
  参考文献：
  名称：

  WO2008/100459

  摘要：

  公开号：

文献信息

• Sulfonamide inhibitors of aspartyl protease
  申请人：Vertex Pharmaceuticals, Incorporated

  公开号：US05585397A1

  公开（公告）日：1996-12-17

  The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HIV-1 and HIV-2 protease activity and consequently, may be advantageously used as anti-viral agents against the HIV-1 and HIV-2 viruses. This invention also relates to methods for inhibiting the activity of HIV aspartyl protease using the compounds of this invention and methods for screening compounds for anti-HIV activity.

  本发明涉及一类新型磺胺类化合物，其为天冬氨酸蛋白酶抑制剂。在一个实施例中，本发明涉及一类新型HIV天冬氨酸蛋白酶抑制剂，其具有特定的结构和理化特征。本发明还涉及包含这些化合物的药物组合物。本发明的化合物和药物组合物特别适用于抑制HIV-1和HIV-2蛋白酶活性，因此，可以有利地用作抗HIV-1和HIV-2病毒的抗病毒剂。本发明还涉及使用本发明的化合物抑制HIV天冬氨酸蛋白酶活性的方法以及筛选具有抗HIV活性的化合物的方法。
• Methods for preparing polymeric reagents and compositions of polymeric reagents
  申请人：Kozlowski Antoni

  公开号：US20080064851A1

  公开（公告）日：2008-03-13

  Methods for preparing active carbonate esters of water-soluble polymers are provided. Also provided are other methods related to the active carbonate esters of water-soluble polymers, as well as corresponding compositions.
• Pharmacodynamically enhanced therapeutic proteins
  申请人：Yesland Kyle D.

  公开号：US20080171696A1

  公开（公告）日：2008-07-17

  Compositions containing an N-linked oligosaccharide having little or no terminal sialic acid residues which is attached to a therapeutic protein that is bonded to a glycol polymer.
• AVIAN DERIVED FUSION PROTEINS
  申请人：Harvey Alex J.

  公开号：US20100062982A1

  公开（公告）日：2010-03-11

  The invention encompasses among other things fusion proteins including Fc fusion proteins such as CTLA4-Fc having avian N-linked glycosylation patterns obtained from egg white of eggs laid by transgenic avians.
• DERIVATIVES AND ANALOGS OF CHROMAN AS FUNCTIONALLY SELECTIVE ALPHA2C ADRENORECEPTOR AGONISTS
  申请人：Zheng Junying

  公开号：US20100168195A1

  公开（公告）日：2010-07-01

  In its many embodiments, the present invention provides a novel class of chroman compounds of formula I as α2C adrenergic receptor agonists, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of prepaxing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more conditions associated with the α2C adrenergic receptors using such compounds or pharmaceutical compositions. wherein J is: Z is —[(C(R c )(R c )] n —, where x is 1, 2, or 3,