US10131664, Example 1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: US10131664, Example 1
• 英文别名: 4-[5-(4-methylphenyl)-1-[[(3R)-pyrrolidin-3-yl]methyl]pyrrolo[3,2-b]pyridin-6-yl]benzonitrile
• 化学式: C₂₆H₂₄N₄
• 分子量: 392.5
• InChiKey: UWAZSGULEBMAMF-HXUWFJFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  53.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• INHIBITORS OF LYSINE SPECIFIC DEMETHYLASE-1
  申请人：Quanticel Pharmaceuticals, Inc.

  公开号：US20160108046A1

  公开（公告）日：2016-04-21

  The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of lysine specific demethylase-1. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.

  本发明一般涉及用于治疗癌症和肿瘤疾病的组合物和方法。本文提供了替代杂环衍生物化合物和包含该化合物的制药组合物。该化合物和组合物对于抑制赖氨酸特异性去甲基化酶-1具有有用性。此外，该化合物和组合物对于治疗癌症，如前列腺癌、乳腺癌、膀胱癌、肺癌和/或黑色素瘤等有用。
• Inhibitors of lysine specific demethylase-1
  申请人：Celgene Quanticel Research, Inc.

  公开号：US10131664B2

  公开（公告）日：2018-11-20

  The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of lysine specific demethylase-1. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.

  本发明一般涉及治疗癌症和肿瘤性疾病的组合物和方法。本发明提供了取代的杂环衍生物化合物和包含所述化合物的药物组合物。所述化合物和组合物可用于抑制赖氨酸特异性去甲基化酶-1。此外，所述化合物和组合物还可用于治疗癌症，如前列腺癌、乳腺癌、膀胱癌、肺癌和/或黑色素瘤等。
• Inhibitor of lysine specific demethylase-1
  申请人：Celgene Quanticel Research, Inc.

  公开号：US10543198B2

  公开（公告）日：2020-01-28

  The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of lysine specific demethylase-1. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.

  本发明一般涉及治疗癌症和肿瘤性疾病的组合物和方法。本发明提供了取代的杂环衍生物化合物和包含所述化合物的药物组合物。所述化合物和组合物可用于抑制赖氨酸特异性去甲基化酶-1。此外，所述化合物和组合物还可用于治疗癌症，如前列腺癌、乳腺癌、膀胱癌、肺癌和/或黑色素瘤等。
• US9822119B2
  申请人：——

  公开号：US9822119B2

  公开（公告）日：2017-11-21
• US9944636B2
  申请人：——

  公开号：US9944636B2

  公开（公告）日：2018-04-17