N-[(2,4-difluorophenyl)methyl]-5-hydroxy-1-(2-methoxyethyl)-3-methyl-4,6-dioxo-spiro[pyrido[2,1-f][1,2,4]triazine-2,3'-tetrahydrofuran]-7-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N-[(2,4-difluorophenyl)methyl]-5-hydroxy-1-(2-methoxyethyl)-3-methyl-4,6-dioxo-spiro[pyrido[2,1-f][1,2,4]triazine-2,3'-tetrahydrofuran]-7-carboxamide
• 英文别名: N-[(2,4-difluorophenyl)methyl]-5'-hydroxy-1'-(2-methoxyethyl)-3'-methyl-4',6'-dioxospiro[oxolane-3,2'-pyrido[2,1-f][1,2,4]triazine]-7'-carboxamide
• 化学式: C₂₂H₂₄F₂N₄O₆
• 分子量: 478.4
• InChiKey: HCOBZQJFKVYVHN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  34
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  112
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• [EN] SPIROCYCLIC HETEROCYCLE COMPOUNDS USEFUL AS HIV INTEGRASE INHIBITORS<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES SPIROCYCLIQUES UTILES EN TANT QU'INHIBITEURS DE L'INTÉGRASE DU VIH
  申请人：MERCK SHARP & DOHME

  公开号：WO2015095258A1

  公开（公告）日：2015-06-25

  The present invention relates to Spirocyclic Heterocycle Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, B, X, Y, R1, R2 and R11 are as defined herein. The present invention also relates to compositions comprising at least one Spirocyclic Heterocycle Compound, and methods of using the Spirocyclic Heterocycle Compounds for treating or preventing HIV infection in a subject.

  本发明涉及式（I）的螺环杂环化合物及其药学上可接受的盐，其中A、B、X、Y、R1、R2和R11如本文所定义。本发明还涉及包含至少一种螺环杂环化合物的组合物，以及使用该螺环杂环化合物治疗或预防受试者HIV感染的方法。
• SPIROCYCLIC HETERCYCLE COMPOUNDS USEFUL AS HIV INTEGRASE INHIBITORS
  申请人：Graham Thomas H.

  公开号：US20160317543A1

  公开（公告）日：2016-11-03

  The present invention relates to Spirocyclic Heterocycle Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, B, X, Y, R 1 , R 2 and R 11 are as defined herein. The present invention also relates to compositions comprising at least one Spirocyclic Heterocycle Compound, and methods of using the Spirocyclic Heterocycle Compounds for treating or preventing HIV infection in a subject.
• US9707234B2
  申请人：——

  公开号：US9707234B2

  公开（公告）日：2017-07-18